A hybrid zinc-calcium-silicate polyalkenoate bone cement
A hybrid zinc-calcium-silicate polyalkenoate bone cement
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DOI：
10.1016/s0142-9612(03)00090-5
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发表时间：
2003-07-01
期刊：
影响因子：
14
通讯作者：
Eberhardt, AW
中科院分区：
文献类型：
--
作者：
Xie, D;Feng, DS;Eberhardt, AW
研制了一种新型的由烧结磷酸锌钙和杂化聚烯烃组成的骨水泥。介绍了玻璃填料、单体和聚合物的合成、配方及水泥的配方。研究了烧结、聚合物含量、玻璃粉/聚合物液（P/L）比和共聚单体对材料抗压强度（CS）和固化时间（CT）的影响。研究了P/L比和共聚单体对收缩率和伸长率的影响。结果表明，与传统的聚甲基丙烯酸甲酯骨水泥相比，实验骨水泥的CS高61%，径向拉伸强度低10%，弯曲强度低35%，弯曲强度低62%，收缩率低68%。随着水泥配方中聚合物含量和P/L比的增加，水泥的CS增加，CT降低。随着P/L比的增大，水泥的固化时间、收缩率和微收缩率均减小。如果这种新型骨水泥具有良好的生物学性能并优化其配方，则其可能成为骨科修复的潜在候选物。(C)2003爱思唯尔科技有限公司版权所有。
A novel bone cement composed of sintered zinc-calcium-silicate phosphate and hybrid polyalkenoates has been developed. Synthesis and formulation of glass fillers, monomers and polymers as well as formulation of the cement were described. The effects of sintering, polymer content, glass powder/polymer liquid (P/L) ratio and comonomer on compressive strength (CS) and curing time (CT) were investigated. The effects of P/L ratio and comonomers on shrinkage as well as exotherm were also studied. Results show that the experimental cement was 61% higher in CS, 10% lower in diametral tensile strength, 35% lower in flexural strength, 62% less in exotherm, and 68% less in shrinkage, compared to conventional polymethylmethacrylate cement. With increasing polymer content and P/L ratio in the cement formulation CS of the cement increased but CT decreased. Curing time, shrinkage and exotherm of the cement decreased with increasing P/L ratio. It appears that this novel cement may be a potential candidate for orthopedic restoration if its biological performance is good and formulation is optimized. (C) 2003 Elsevier Science Ltd. All rights reserved.