Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S
Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S
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青霉类固醇 A 和 B，来自海洋藻类内生真菌产黄青霉 QEN-24S 的抗真菌和细胞毒性多氧类固醇
DOI：
10.1016/j.bmcl.2011.03.076
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发表时间：
2011-05-15
影响因子：
2.7
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Gao, Shu-Shan;Li, Xiao-Ming;Wang, Bin-Gui
从产黄青霉（Penicillium chrysogenum QEN-24 S）的培养物中分离得到两个新的多氧甾体化合物，即青霉甾体A和B（1和2）。此外，还分离和鉴定了7种已知的类固醇（3-9）。这些化合物的结构是建立在广泛的光谱分析的基础上。通过应用改进的Mosher方法确定化合物1的绝对构型。青霉甾类化合物A（1）是一种结构独特的甾体化合物，具有四羟基和C-16-乙酰氧基，在初步的生物测定中显示出有效的抗真菌和细胞毒活性。初步的构效关系进行了讨论。(C)2011爱思唯尔有限公司保留所有权利。
Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved.