Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan.
Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan.
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DOI：
10.1371/journal.pone.0139154
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chiu MJ
中科院分区：
文献类型：
--
作者：
Fan LY;Sun Y;Lee HJ;Yang SC;Chen TF;Lin KN;Lin CC;Wang PN;Tang LY;Chiu MJ
在亚洲，生活方式、婚姻状况和痴呆风险之间存在关联的证据有限。本研究以全国人口横断面调查为基础，以电脑随机抽样的方式，从全台湾19个县市选取调查对象。通过上门调查，共对10432名居民进行了评估，其中7035人正常，929人根据国家老龄化研究所-阿尔茨海默病协会推荐的标准被诊断为痴呆症。对正常受试者和痴呆患者的发病前生活习惯和包括婚姻状况在内的人口统计数据进行了比较。在调整了年龄、性别、受教育程度、体重指数、吸烟、饮酒、婚姻状况、睡眠习惯、运动、社会参与以及高血压、糖尿病和脑血管疾病等合共病后，发现丧偶或鳏夫状态的人群（or 1.42, 95% CI 1.15-1.77）和习惯在下午午睡的人群（or 1.33, 95% CI 1.02-1.72）患痴呆的风险增加。有规律运动习惯的人（OR 0.12, 95% CI 0.09-0.16）、充足的夜间睡眠（OR 0.55, 95% CI 0.39-0.76）和有规律的社交活动（OR 0.53, 95% CI 0.36-0.77）的风险降低。我们的研究结果提供了可能降低痴呆症风险的初步证据，包括适量的定期锻炼、社交活动和充足的夜间睡眠，而寡妇/鳏夫状态或过去经常午睡的人可能会增加患痴呆症的风险。
Evidence of an association between lifestyle and marital status and risk of dementia is limited in Asia. In this nationwide population-based cross-sectional survey, participants were selected by computerized random sampling from all 19 counties in Taiwan. A total of 10432 residents were assessed by a door-to-door in-person survey, among whom 7035 were normal and 929 were diagnosed with dementia using the criteria recommended by National Institute on Aging-Alzheimer’s Association. Premorbid lifestyle habits and demographic data including marital status were compared between normal subjects and participants with dementia. After adjustment for age, gender, education, body mass index, smoking, drinking, marital status, sleep habits, exercise, social engagement and co-morbidities including hypertension, diabetes and cerebrovascular diseases, an increased risk for dementia was found in people with widow or widower status (OR 1.42, 95% CI 1.15–1.77) and people who used to take a nap in the afternoon (OR 1.33, 95% CI 1.02–1.72). Decreased risk was found in people with the habit of regular exercise (OR 0.12, 95% CI 0.09–0.16), adequate night sleep (OR 0.55, 95% CI 0.39–0.76) and regular social engagement (OR 0.53, 95% CI 0.36–0.77). Our results provide preliminary evidence of possible risk-reduction effects for dementia, including regular exercise even in modest amounts, social engagement and adequate night sleep, whereas people with the widow/widower status or who used to take an afternoon nap might have increased risk of dementia.