Monte Carlo simulation in PET and SPECT instrumentation using GATE
Monte Carlo simulation in PET and SPECT instrumentation using GATE
复制标题
DOI：
10.1016/j.nima.2004.03.117
复制
发表时间：
2004-07-11
影响因子：
1.4
通讯作者：
Van de Walle, R
中科院分区：
文献类型：
--
作者：
Assié, K;Breton, V;Van de Walle, R
蒙特卡罗模拟是帮助设计新的发射断层成像医学成像设备的必要工具。一方面，已经开发了用于PET和SPECT的专用蒙特卡罗程序。然而，它们在有效性、准确性和/或支持方面存在各种缺陷和限制。另一方面，已经为高能物理编写了精确和通用的模拟程序，如GEANT3、EGS4、MCNP和最近的GEANT4。它们都包括经过充分验证的物理模型、几何建模工具和高效的可视化工具。然而，这些套餐相当复杂，需要经历一段陡峭的学习曲线。GATE是用于断层扫描发射的GEANT4应用程序，它封装了GEANT4库，以实现适合核医学领域的模块化、通用、脚本化的模拟工具包。特别是，GATE允许用户描述与时间相关的现象，如探测器移动或源衰减动力学，从而允许模拟现实采集条件下的时间曲线。目前，它正在OpenGate协作中进一步开发和验证。我们对GATE进行了简要的概述，并给出了四个用PET和SPECT相机获得的真实数据进行验证的例子。(C)2004爱思唯尔B.V.保留所有权利。
Monte Carlo simulation is an essential toot to assist in the design of new medical imaging devices for emission tomography. On one hand, dedicated Monte Carlo codes have been developed for PET and SPECT. However, they suffer from a variety of drawbacks and limitations in terms of validation, accuracy, and/or support. On the other hand, accurate and versatile simulation codes such as GEANT3, EGS4, MCNP, and recently GEANT4 have been written for high energy physics. They all include well-validated physics models, geometry modeling tools and efficient visualization utilities. Nevertheless these packages are quite complex and necessitate a steep learning curve. GATE, the GEANT4 Application for Tomographic Emission, encapsulates the GEANT4 libraries in order to achieve a modular, versatile, scripted simulation toolkit adapted to the field of nuclear medicine. In particular, GATE allows the users to describe time-dependent phenomena such as detector movements or source decay kinetics, thus allowing to simulate time curves under realistic acquisition conditions. At present, it is being further developed and validated within the OpenGATE Collaboration. We give a succinct overview of GATE and four examples of its validation against real data obtained with PET and SPECT cameras. (C) 2004 Elsevier B.V. All rights reserved.