Delirium and neuropsychological recovery among emergency general surgery survivors (DANE): study protocol for a randomized controlled trial and collaborative care intervention.
Delirium and neuropsychological recovery among emergency general surgery survivors (DANE): study protocol for a randomized controlled trial and collaborative care intervention.
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谵妄是一种复杂的神经精神综合征，包括认知和意识的急性和不同的变化。发生谵妄的患者在谵妄结束后很长一段时间内发生一系列身体、认知和心理残疾的风险增加。协作护理模式整合初级和专科护理，以满足复杂的生物心理社会需求的患者已被证明，以改善慢性病患者的结果。本研究的目的是评估协作护理模式对急诊手术后谵妄幸存者神经心理恢复的能力。本方案描述了一项多中心（三个州的八家医院）随机对照试验，其中528例急诊手术后发生谵妄的患者将随机分配至协作护理模式或常规护理。协作护理模式对这些谵妄幸存者的认知、身体和心理恢复的疗效将在18个月内进行评估。这将是在术后谵妄幸存者中进行的首批随机临床试验，评估旨在减轻谵妄下游影响并改善术后神经心理恢复的干预措施。我们希望这项研究的结果将增加和告知策略，以改善这一患者群体的术后恢复。ClinicalTrials.gov NCT05373017。于2022年5月12日注册。
Delirium is a complex neuropsychiatric syndrome which consists of acute and varying changes in cognition and consciousness. Patients who develop delirium are at increased risk for a constellation of physical, cognitive, and psychological disabilities long after the delirium has ended. Collaborative care models integrating primary and specialty care in order to address patients with complex biopsychosocial needs have been demonstrated to improve outcomes in patients with chronic diseases. The purpose of this study is to evaluate the ability of a collaborative care model on the neuropsychologic recovery of delirium survivors following emergency surgery. This protocol describes a multicenter (eight hospitals in three states) randomized controlled trial in which 528 patients who develop delirium following emergency surgery will be randomized to either a collaborative care model or usual care. The efficacy of the collaborative care model on cognitive, physical, and psychological recovery in these delirium survivors will then be evaluated over 18 months. This will be among the first randomized clinical trials in postoperative delirium survivors evaluating an intervention designed to mitigate the downstream effects of delirium and improve the neuropsychologic recovery after surgery. We hope that the results of this study will add to and inform strategies to improve postoperative recovery in this patient group. ClinicalTrials.gov NCT05373017. Registered on May 12, 2022.
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影响因子：
158.5
作者：
Inouye, SK;Bogardus, ST;Cooney, LW
通讯作者：
Cooney, LW
影响因子：
168.9
作者：
Inouye, Sharon K.;Westendorp, Rudi G. J.;Saczynski, Jane S.
通讯作者：
Saczynski, Jane S.
影响因子：
11
作者：
Wade, DT;King, NS;Caldwell, FE
通讯作者：
Caldwell, FE
影响因子：
4.7
作者：
Ghaffar, Omar;McCullagh, Scott;Feinstein, Anthony
通讯作者：
Feinstein, Anthony
DOI：
10.1046/j.1532-5415.2001.49108.x
发表时间：
2001-05-01
影响因子：
6.3
作者：
Marcantonio, ER;Flacker, JM;Resnick, NM
通讯作者：
Resnick, NM