Hepatitis C Virus Infection and Treatment as Independent Prognostic Factors in Diffuse Large B-Cell Lymphoma Egyptian Patients
Hepatitis C Virus Infection and Treatment as Independent Prognostic Factors in Diffuse Large B-Cell Lymphoma Egyptian Patients
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DOI：
10.2174/1568009620666200511084731
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Suliman, Marwa A.
中科院分区：
文献类型：
--
作者：
Elbedewy, Tamer A.;Elashtokhy, Hossam Eldin A.;Suliman, Marwa A.
背景：埃及是丙型肝炎病毒(丙型肝炎病毒)高发地区之一。慢性丙型肝炎病毒感染有肝外表现，包括非霍奇金淋巴瘤(NHL)。弥漫性大B细胞淋巴瘤(DLBCL)通常与丙型肝炎病毒感染有关。丙型肝炎病毒感染和丙型肝炎病毒治疗对埃及DLBCL患者的预后价值目前尚不清楚。目的：本研究的目的是评价丙型肝炎病毒感染和丙型肝炎病毒治疗作为独立预后因素对埃及地区丙型肝炎病毒相关性DLBCL患者无事件生存(EFS)和总生存期(OS)的影响。前瞻性收集接受抗病毒治疗的34例丙型肝炎患者。患者的特征是从诊断时的患者记录中收集的。记录患者的丙型肝炎病毒感染情况和丙型肝炎病毒治疗情况。疾病进展、复发、再治疗或死亡也通过医疗记录得到核实。结果：丙型肝炎病毒感染者和丙型肝炎病毒未治疗患者的EFS和OS分别比未感染和治疗的患者显著降低。结论：丙型肝炎病毒感染是影响弥漫性大B细胞淋巴瘤患者EFS和OS的独立预后因素。丙型肝炎病毒治疗与较高的EFS和OS相关，但不能被视为独立的预后因素。
Background: Egypt is one of the highest hepatitis C virus (HCV) endemic areas. Chronic HCV infection has extra-hepatic manifestations, including non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is commonly associated with HCV infection. The prognostic value of HCV infection and HCV treatment in patients with DLBCL remains unclear until now.Objective: The aim of our study is to evaluate the impact of HCV infection and HCV treatment as independent prognostic factors on the event-free survival (EFS) and overall survival (OS) in Egyptian patients with HCV associated DLBCL.Methods: This study included 353 patients with DLBCL, collected retrospectively. While 34 patients with HCV who received HCV antiviral therapy were collected prospectively. Patient's characteristics were collected from the patient records at the time of diagnosis. The status of the patients about HCV infection and HCV treatment were also recorded. Disease progression, relapse, retreatment or deaths were also verified through medical records. EFS and OS were calculated.Results: EFS and OS significantly decrease in HCV infected and HCV non-treated patients when compared with HCV non-infected and HCV treated patients, respectively. HCV infection but not HCV treatment was independently associated with EFS and OS using univariate and multivariate analysis.Conclusion: Hepatitis C virus infection is an independent prognostic factor for EFS and OS in diffuse large B-cell lymphoma. HCV treatment is associated with higher EFS and OS but can not be considered as an independent prognostic factor.