Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
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DOI：
10.1016/j.rmed.2009.01.021
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发表时间：
2009-08-01
影响因子：
4.3
通讯作者：
Tohda, Yuji
中科院分区：
文献类型：
--
作者：
Higashimoto, Yuji;Iwata, Takuya;Tohda, Yuji
研究背景：近年来研究表明，COPD患者全身炎症程度较轻，血浆纤维蛋白原和中性粒细胞水平较高。计数与肺功能的快速下降有关。方法：选取9种血清生物标志物（TIMP-1、α 1-抗胰蛋白酶、MMP-9、TNF-α、TGF-β、IL-6、IL-8、中性粒细胞）作为研究对象，测定其基线水平。弹性蛋白酶和CRP）、纤维蛋白原和白色血细胞。测定96例COPD患者的WCC。结果：肺功能快速下降者20例，非下降者53例。诺维茨基快速下降组血清CRP、MMP-9水平明显高于快速下降组（P < 0.05）。FEV1%预测值的年变化与MMP-9（r = -0.288; p < 0.01）和CRP（r = -0.354; p < 0.005）呈负相关（偏相关系数校正了年龄、性别、心血管疾病、吸烟史和基线FEV1%预测值）。其余指标与FEV 1预测值%的年变化无相关性。结论：血清CRP和MMP-9水平与FEV 1下降有关。这些指标是预测COPD患者FEV 1快速下降的良好候选指标。对COPD患者进行更多的长期和更大规模的研究可能有助于确定这些生物标志物的确切作用。(C)2009 Elsevier Ltd. All. rights reserved.
Background: Recent studies show that COPD patients exhibit low-grade systemic inflammation, and that plasma fibrinogen and high neutrophil. counts are related to faster declines in lung function. We examined correlations between serum biomarkers and the decline of lung function in COPD patients.Method: Baseline levels of 9 serum biomarkers (TIMP-1, alpha 1-antitrypsin, MMP-9, TNF-alpha, TGF-beta, IL-6, IL-8, neutrophil. elastase and CRP), fibrinogen and white blood cell. counts (WCC) were measured in 96 COPD patients. Lung function was measured at the time of blood sampling and every 3-6 months during the observation period (median 25.0 months).Results: Twenty patients were rapid decliners of tung function and 53 patients were non-decliners. Neutrophil. counts, serum CRP and MMP-9 were significantly higher in the rapid decliners (p < 0.05). The annual change of % predicted FEV1 was inversely correlated with MMP-9 (r = -0.288; p < 0.01) and CRP (r = -0.354; p < 0.005) (partial correlation coefficients adjusted for age, sex, cardiovascular disease, smoking history, and baseline % predicted FEV1). The remaining biomarkers were not correlated with the annual change of % predicted FEV1.Conclusion: Serum CRP and MMP-9 levels were related to FEV1 decline. These markers are good candidates as predictors for rapid decline of FEV1 in COPD patients. Additional long-term and larger size studies of COPD patients could help determine the exact rotes for these biomarkers. (C) 2009 Elsevier Ltd. All. rights reserved.