SEGMENTAL ORGANIZATION OF EMBRYONIC DIENCEPHALON
SEGMENTAL ORGANIZATION OF EMBRYONIC DIENCEPHALON
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DOI：
10.1038/363630a0
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发表时间：
1993-06-17
期刊：
影响因子：
64.8
通讯作者：
STERN, CD
中科院分区：
文献类型：
--
作者：
FIGDOR, MC;STERN, CD
间脑是脊椎动物大脑的一个复杂的整合中心和复杂的中继站1-3。它的发展涉及巨大的细胞多样性和神经元特异性的产生。我们在这里报告说，它通过神经元细分的刻板序列逐步组织起来。间脑神经节定义了四个可以在整个发育过程中遵循的细胞结构域（D1-D4），每个单元都有助于成人结构模式的明确部分。我们提出，每个间脑单位的节段身份是由基因 4-13 的独特组合指定的，并由多克隆细胞谱系限制维持。脊椎动物和节肢动物发育的比较表明，控制前轴模式和在胚胎中枢神经系统中建立神经元特异性的基本原理在进化中高度保守。
THE diencephalon is a complex integration centre and intricate relay station of the vertebrate brain1-3. Its development involves the generation of great cellular diversity and neuronal specificity. We report here that it becomes organized in steps, through a stereotyped sequence of neuromeric subdivisions. Diencephalic neuromeres define four cellular domains (D1-D4) that can be followed throughout development, each unit contributing to a well defined part of the adult structural pattern. We propose that the segmental identity of each diencephalic unit is specified by a unique combination of genes4-13, maintained by polyclonal cell lineage restrictions. A comparison of vertebrate and arthropod development suggests that the basic principles that control anterior axial patterning and set up neuronal specificity in the embryonic central nervous system are highly conserved in evolution.