Snake venom disintegrins:: evolution of structure and function
Snake venom disintegrins:: evolution of structure and function
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DOI：
10.1016/j.toxicon.2005.02.024
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发表时间：
2005-06-15
期刊：
影响因子：
2.8
通讯作者：
Sanz, L
中科院分区：
文献类型：
--
作者：
Calvete, JJ;Marcinkiewicz, C;Sanz, L
去整合素代表存在于各种毒蛇毒液中的多肽家族，其选择性地阻断整合素受体的功能。在这里，我们回顾了我们目前的观点和假说的出现和结构和功能多样化的去整合素的加速进化和选择性损失的二硫键的重复基因。对去整合素的研究与理解蝰蛇毒毒素的生物学有关，但也提供了可能在基础和临床研究中有用的整合素识别所涉及的新结构决定因素的信息。的组合物，构象，和动态的整合素抑制环与C-末端尾巴在确定的选择性抑制整合素受体的协同作用的作用进行了讨论。(c)2005爱思唯尔有限公司保留所有权利。
Disintegrins represent a family of polypeptides present in the venoms of various vipers that selectively block the function of integrin receptors. Here, we review our current view and hypothesis on the emergence and the structural and functional diversification of disintegrins by accelerated evolution and the selective loss of disulfide bonds of duplicated genes. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information on new structural determinants involved in integrin recognition that may be useful in basic and clinical research. The role of the composition, conformation, and dynamics of the integrin inhibitory loop acting in concert with the C-terminal tail in determining the selective inhibition of integrin receptors is discussed. (c) 2005 Elsevier Ltd. All rights reserved.