Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol
Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol
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DOI：
10.1016/j.chemosphere.2012.05.015
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发表时间：
2012-10-01
期刊：
影响因子：
8.8
通讯作者：
Huff, James
中科院分区：
文献类型：
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作者：
Huff, James
通过在饲料中给 50 只雄性和雌性 Fischer 大鼠以及雄性 B6C3F1 小鼠喂食 2,4,6-三氯苯酚 [2,4,6-TCP]，进行为期两年的致癌生物测定。膳食浓度为 0 [20/组]、5000 [0.5%] 或 10,000 [1%] ppm。雌性小鼠开始时的浓度为 10,000 和 20,000 ppm，但 38 周后，由于体重减轻，浓度降低至 2500 和 5000 ppm，持续 67 周：平均暴露量为 5200 和 10,400 ppm。两年时的不良反应是两性大鼠外周血白细胞和单核细胞增多以及骨髓增生。在小鼠中，通常存在肝毒性，包括个别肝细胞异常、细胞改变的局灶性区域以及增生的局灶性和结节性区域。关于致癌活性，TCP 在雄性大鼠中引起白血病/淋巴瘤，也可能在雌性大鼠和雌性小鼠中引起白血病/淋巴瘤，并在雄性和雌性小鼠中诱发肝脏肿瘤。使用 NTP 类别的证据表明雄性大鼠有“明确的致癌性证据”[造血系统肿瘤]；雌性大鼠的“致癌性的模棱两可的证据”[造血系统肿瘤]；对雄性和雌性小鼠[肝脏肿瘤]有“明确的致癌性证据”。由爱思唯尔有限公司出版
Carcinogenesis bioassays were conducted by giving 2,4,6-trichlorophenol [2,4,6-TCP] in feed to groups of 50 male and female Fischer rats and male B6C3F1 mice for two years. Dietary concentrations were 0 [20/group], 5000 [0.5%], or 10,000 [1%] ppm. Female mice began with 10,000 and 20,000 ppm but after 38 weeks were lowered due to reduced body weights to 2500 and 5000 ppm for 67 weeks: exposures averaged 5200 and 10,400 ppm. Adverse effects at two years were leukocytosis and monocytosis of peripheral blood and hyperplasia of bone marrow in both sexes of rats. In mice, liver toxicity, including individual liver cell abnormalities, focal areas of cellular alteration, and focal and nodular areas of hyperplasia were commonly present. Regarding carcinogenic activity, TCP caused leukemias/lymphomas in male rats, and possibly in female rats and female mice as well, and induced liver tumors in male and female mice. Using NTP categories of evidence indicates 'clear evidence of carcinogenicity' for male rats [hematopoietic system tumors]; 'equivocal evidence of carcinogenicity' for female rats [hematopoietic system tumors]; 'clear evidence of carcinogenicity' for male and female mice [liver tumors]. Published by Elsevier Ltd.