The neural stem cell secretome across neurodevelopment
The neural stem cell secretome across neurodevelopment
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DOI：
10.1016/j.expneurol.2022.114142
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发表时间：
2022-09-01
影响因子：
5.3
通讯作者：
Kirby，Elizabeth D.
中科院分区：
文献类型：
--
作者：
Dause，Tyler J.;Denninger，Jiyeon K.;Kirby，Elizabeth D.
基于神经干细胞（NSC）的疗法处于再生医学策略的最前沿，以对抗中枢神经系统（CNS）的疾病和损伤。除了它们产生新细胞的能力之外，NSC还分泌各种产物，统称为NSC分泌组，其已被证明可以改善CNS疾病病理学并促进恢复。随着利用NSC分泌组用于治疗目的的临床前和临床研究的进展，对内源性NSC分泌组的更彻底的理解可以提供对NSC功能能力的有用见解。在这篇综述中，我们重点研究调查的自分泌和旁分泌功能的内源性神经干细胞分泌组在生活中。在整个发育和成年期，我们发现证据表明NSC分泌组是内源性NSC如何调节自身及其生态位的关键组成部分。我们还发现了目前文献中的空白，最明显的是在临床相关领域的内源性神经干细胞旁分泌功能损伤的中枢神经系统。未来的调查，以进一步确定内源性神经干细胞分泌组及其在中枢神经系统组织调节的作用是必要的，以加强我们的理解，神经干细胞的生态位的相互作用，并帮助在安全和有效的神经干细胞为基础的治疗的产生。
Neural stem cell (NSC) based therapies are at the forefront of regenerative medicine strategies to combat illness and injury of the central nervous system (CNS). In addition to their ability to produce new cells, NSCs secrete a variety of products, known collectively as the NSC secretome, that have been shown to ameliorate CNS disease pathology and promote recovery. As pre-clinical and clinical research to harness the NSC secretome for therapeutic purposes advances, a more thorough understanding of the endogenous NSC secretome can provide useful insight into the functional capabilities of NSCs. In this review, we focus on research investigating the autocrine and paracrine functions of the endogenous NSC secretome across life. Throughout development and adulthood, we find evidence that the NSC secretome is a critical component of how endogenous NSCs regulate themselves and their niche. We also find gaps in current literature, most notably in the clinically-relevant domain of endogenous NSC paracrine function in the injured CNS. Future investigations to further define the endogenous NSC secretome and its role in CNS tissue regulation are necessary to bolster our understanding of NSC-niche interactions and to aid in the generation of safe and effective NSC-based therapies.