POSTNATAL-DEVELOPMENT OF PARVALBUMIN IMMUNOREACTIVITY IN THE CEREBRAL-CORTEX OF THE CAT
POSTNATAL-DEVELOPMENT OF PARVALBUMIN IMMUNOREACTIVITY IN THE CEREBRAL-CORTEX OF THE CAT
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DOI：
10.1002/cne.903480108
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发表时间：
1994-10-01
影响因子：
2.5
通讯作者：
FERRER, I
中科院分区：
文献类型：
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作者：
ALCANTARA, S;FERRER, I
小清蛋白免疫反应性在发展中的新皮质的猫的进展后，特定的层流，面积，并在一个特定的领域，大致前后梯度。小清蛋白免疫反应性首先发生在篮状细胞，后来在枝状神经元。第2 ~ 3周，在听觉相关区的V层也短暂地观察到锥体样免疫反应神经元。Parvalbumin免疫反应神经元首先出现在初级躯体感觉皮层和初级听觉和视觉区，其次是初级运动和多感觉联合区，最后，听觉联合区和皮质区相关的边缘系统。除了皮质神经元，三个纤维系统的免疫标记与antiparvalbumin抗体：丘脑皮质，胼胝体，和同侧皮质。在出生后的第一个月出现了小清蛋白免疫反应性丘脑皮质纤维。从出生后第四周起，可见小清蛋白免疫反应胼胝体和同侧皮质纤维。由于所有的小白蛋白免疫反应的皮质神经元在成年期是非锥体抑制细胞，目前的研究结果表明，一些同侧皮质和胼胝体连接可能是抑制性的。(C)1994 Wiley-Liss，Inc.
Parvalbumin immunoreactivity in the developing neocortex of the cat progresses following specific laminar, areal, and, in a particular area, roughly anteroposterior gradients. Parvalbumin immunoreactivity first occurs in basket cells and later in chandelier neurons. Pyramid-like immunoreactive neurons are also transitorily observed from the second to the third week in layer V of the auditory association-related areas. Parvalbumin-immunoreactive neurons first appear in the primary somatosensory cortex and primary auditory and visual areas, followed by the primary motor and polysensory association areas and, finally, the auditory association areas and cortical areas related to the limbic system.In addition to cortical neurons, three fiber systems are immunolabeled with antiparvalbumin antibodies: thalamocortical, callosal, and ipsilateral corticocortical. Parvalbumin-immunoreactive thalamocortical fibers appear during the first month of postnatal life. Parvalbumin-immunoreactive callosal and ipsilateral corticocortical fibers are seen from the fourth postnatal week onward. Because all parvalbumin-immunoreactive cortical neurons in adulthood are nonpyramidal inhibitory cells, the present findings suggest that a number of ipsilateral corticocortical and callosal connections may be inhibitory. (C) 1994 Wiley-Liss, Inc.