Effectiveness of the interventions in preventing the progression of pre-frailty and frailty in older adults: a systematic review protocol.
Effectiveness of the interventions in preventing the progression of pre-frailty and frailty in older adults: a systematic review protocol.
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DOI：
10.11124/jbisrir-2016-2467
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Holland, Carol
中科院分区：
文献类型：
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作者：
Apostolo, Joao;Cooke, Richard;Holland, Carol
BackgroundFrailty is an age-related state of high vulnerability to adverse health outcomes after a stressor event 1–6, predisposing the individuals to falls and fractures, disability, dependency, hospitalization and institutional placement, and ultimately death. 1 It can be preceded by, but also occurs in the absence of, chronic disease. 3, 5, 7 According to some authors, this clinical condition results from decrease in reserves across multiple physiological systems that are normally responsible for healthy adaptation to stress. 1, 8, 9 Alternatively, it is considered that frailty is due to the critical accumulation of dysregulation in important signaling pathways and subsequent depletion of homeostatic reserve and resiliency. 1, 10, 11 Other authors describe this state of increased vulnerability as associated with a reduced capacity to compensate aging-related molecular and cellular damage. 2 Independently of pathophysiological conceptualization, it is assumed that frailty is a dynamic process that leads to a spiraling decline in various functional domains that exacerbates the risk of geriatric syndromes. 1, 3, 5, 6
