Barrier function of the coelomic epithelium in the developing pancreas.
Barrier function of the coelomic epithelium in the developing pancreas.
复制标题
发育中的胰腺中体腔上皮的屏障功能。
DOI：
10.1016/j.mod.2014.09.004
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发表时间：
2014
影响因子：
2.6
通讯作者：
Gittes,George
中科院分区：
文献类型：
--
作者：
Guo,Ping;Preuett,Barry;Krishna,Prasadan;Xiao,Xiangwei;Shiota,Chiyo;Wiersch,John;Gaffar,Iliana;Tulachan,Sidhartha;El-Gohary,Yousef;Song,Zewen;Gittes,George
在发育胚胎的封闭范围内，细胞外形态发生素信号的紧密空间调节对于适当的器官发生至关重要。考虑到发育器官中细胞外信号的复杂性，以及使用不同信号通路的相邻器官的接近性，我们假设胚胎器官之间可能存在信号传导的物理屏障。在这里，我们描述了一个以前未被认识到的作用，胚胎体腔上皮细胞在提供一个物理屏障，包含在发育中的小鼠胰腺形态发生信号。这层细胞似乎既包含胰腺上皮分化所需的关键因子，又在关键的发育窗口期间防止相邻器官的融合。在早期前肠发育过程中，这种屏障似乎在防止脾原基衍生的激活素信号传导诱导胰腺特异性上皮细胞的增殖中起作用。
Tight spatial regulation of extracellular morphogen signaling within the close confines of a developing embryo is critical for proper organogenesis. Given the complexity of extracellular signaling in developing organs, together with the proximity of adjacent organs that use disparate signaling pathways, we postulated that a physical barrier to signaling may exist between organs in the embryo. Here we describe a previously unrecognized role for the embryonic coelomic epithelium in providing a physical barrier to contain morphogenic signaling in the developing mouse pancreas. This layer of cells appears to function both to contain key factors required for pancreatic epithelial differentiation, and to prevent fusion of adjacent organs during critical developmental windows. During early foregut development, this barrier appears to play a role in preventing splenic anlage-derived activin signaling from inducing intestinalization of the pancreas-specified epithelium.