Development of an ionization method using hydrogenated plasma for mass analysis of surface adhesive compounds
Development of an ionization method using hydrogenated plasma for mass analysis of surface adhesive compounds
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开发使用氢化等离子体对表面粘合剂化合物进行质量分析的电离方法
DOI：
10.1039/c7ja00314e
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发表时间：
2018
影响因子：
3.4
通讯作者：
Akitoshi Okino
中科院分区：
文献类型：
--
作者：
Mari Aida;Takahiro Iwai;Yuki Okamoto;Hidekazu Miyahara;Seto Yasuo;Akitoshi Okino
目前，大气等离子体被应用于表面粘附材料的解吸和电离，以进行快速和高灵敏度的分析。一种广泛使用的化学电离方法将从大气水分子产生的质子应用于解吸的样品;然而，迄今为止尚未解决电离机制的详细研究。因此，本文提出了一种电离方法，即在氦等离子体中加入少量的、优化量的氢，用于在样品电离源中产生质子。使用该技术，对2-异丙基吡啶和4-异丙基苯胺的样品表面沉积物进行质谱分析。氢气流量为2%的添加比例进行了优化，达到的最低检测限为0.1和42 pmol的2-异丙基吡啶和4-异丙基苯胺，分别为。通过优化氢添加流量，获得了用于样品电离的最佳质子数，并且可以实现样品中质子含量的控制，而与质谱分析期间的湿度和周围环境因素无关。
Currently, atmospheric plasmas are applied to the desorption and ionization of surface adhesive materials for rapid and highly sensitive analysis. One widely used chemical ionization method applies protons generated from atmospheric water molecules to a desorbed sample; however, a detailed study of the ionization mechanism has not been addressed thus far. Therefore, this paper proposes an ionization method that adds a small, optimized amount of hydrogen to the helium plasma for generating protons in the sample ionization source. Using this technique, mass spectrometry was performed on the sample surface deposits of 2-isopropylpyridine and 4-isopropylaniline. The hydrogen flow rate was optimized to the addition ratio of 2%, and the lowest limit of detection achieved is 0.1 and 42 pmol for 2-isopropylpyridine and 4-isopropylaniline, respectively. By optimizing the hydrogen addition flow rate, the optimum number of protons for sample ionization was attained, and it became possible to realize control of proton content in the sample, irrespective of humidity and surrounding environmental factors during mass spectrometry.