The C. elegansflr-3(ut9) mutation is a loss-of-function insertion within the drl-1 locus.
The C. elegansflr-3(ut9) mutation is a loss-of-function insertion within the drl-1 locus.
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DOI：
10.17912/micropub.biology.001047
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发表时间：
2023
影响因子：
--
通讯作者：
Dowen, Robert H
中科院分区：
文献类型：
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作者：
Honey, Kendra L;Torzone, Sarah K;Dowen, Robert H
The genes encoding the mitogen-activated protein kinases DRL-1 and FLR-4 are required for growth and lipid homeostasis in C. elegans . Interestingly, the flr-3 ( ut9 ) mutant, which was previously isolated in a forward genetic screen for mutations that confer fluoride resistance, phenocopies the drl-1 and flr-4 loss-of-function mutants; however, the genetic identity of flr-3 is unknown. Through whole genome sequencing, we found that the flr-3 ( ut9 ) mutation is an insertion in the drl-1 locus and disrupts drl-1 gene function, resulting in dramatic growth defects and impaired vitellogenin production.
