ANTIGRANULOMA ACTIVITY OF IRAQI WITHANIA-SOMNIFERA
ANTIGRANULOMA ACTIVITY OF IRAQI WITHANIA-SOMNIFERA
复制标题
DOI：
10.1016/0378-8741(92)90069-4
复制
发表时间：
1992-09-01
影响因子：
5.4
通讯作者：
ABDULNABI, MH
中科院分区：
文献类型：
--
作者：
ALHINDAWI, MK;ALKHAFAJI, SH;ABDULNABI, MH
通过在大鼠皮下植入棉球，确定了睡茄地上部分提取物的不同部分的肉芽肿组织形成抑制活性，植物提取物的甲醇部分保留了抗炎活性，并且与 5 mg/kg 剂量的氢化可的松琥珀酸钠的抗炎活性相当。活性归因于植物中高含量的生物活性类固醇，其中醉茄素 A 是已知的主要成分。
The granuloma-tissue formation inhibiting activity of various fractions of an extract of the aerial parts of Withania somnifera were established using subcutaneous cotton-pellet implantation in rats, Antiinflammatory activity was retained in the methanolic fractions of the plant extract and was comparable to that of a 5 mg/kg dose of hydrocortisone sodium succinate. Activity was attributed to the high content of biologically active steroids in the plant, of which withaferin A is known to be a major component.