Naturally occurring enzyme activity variation in Drosophila melanogaster. I. Sources of variation for 23 enzymes.
Naturally occurring enzyme activity variation in Drosophila melanogaster. I. Sources of variation for 23 enzymes.
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DOI：
10.1093/genetics/102.2.191
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发表时间：
1982-10
期刊：
影响因子：
3.3
通讯作者：
C. C. Laurie-Ahlberg-C.;A. Wilton;J. Curtsinger;T. H. Emigh
中科院分区：
文献类型：
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作者：
C. C. Laurie-Ahlberg-C.;A. Wilton;J. Curtsinger;T. H. Emigh
利用48个自然群体的第二和第三染色体等基因代换系研究了果蝇酶活性水平变异的遗传成分。这些结果证实了我们早期用相同品系进行的实验，并将其扩展到许多其他酶。所有23种酶都显示出一组或两组品系中的变异的显著遗传成分，并且这种变异中只有一小部分是由品系之间每只果蝇的组织量的变异引起的。在大多数情况下，谱线效应的大小要比环境和测量误差效应的大小大得多，并且谱线效应的分布近似连续。染色体的地理起源和核型的变异通常不会导致变异的品系成分，但等位酶为一些酶提供了重要的变异来源。许多酶显示出与酶的结构位点无关的活性修饰剂的变化的证据。
The genetic component of variation of enzyme activity levels in Drosophila melanogaster was investigated by using 48 second- and 48 third-chromosome isogenic substitution lines derived from natural populations. The results confirm those of our earlier experiments with the same lines and extend them to a number of additional enzymes. All 23 enzymes show a significant genetic component to the variation in one or both sets of lines and only a small part of this variation is accounted for by variation among the lines in the amount of tissue per fly. The magnitude of line effects is, in most cases, considerably larger than the magnitude of environmental and measurement error effects, and the line effects are approximately continuous in distribution. Variation in the geographic origin and karyotype of the chromosomes generally does not contribute to the line component of variation, but allozymes provide an important source of variation for a few of the enzymes. Many of the enzymes show evidence for variation of activity modifiers that are not linked to the structural locus of the enzyme.