Metabolic derivatives of aldosterone.
Metabolic derivatives of aldosterone.
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醛固酮的代谢衍生物。
DOI：
10.1152/ajprenal.1987.252.3.f365
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Brem,AS
中科院分区：
文献类型：
--
作者：
Morris,DJ;Brem,AS
在激素作用前的潜伏期内，醛固酮的代谢可能具有重要的生理意义。在大鼠体内，肝脏以性别依赖的方式代谢醛固酮；在雄性大鼠肾脏中发现了更多的中性和还原的醛固酮衍生物；这与雄性大鼠对醛固酮的更大生理反应有关。靶组织，哺乳动物的肾脏和蟾蜍的膀胱，也能够将醛固酮原位代谢到中性极性、5α和5β还原以及一硫酸盐的衍生物。这5种α-还原代谢物具有显著的抗心钠素活性，并优先由大鼠肾核合成。导致合成5种α-还原代谢物及其随后的中性极性衍生物的代谢途径似乎受饮食钠的调节，并可被抗盐皮质激素抑制。在略高于醛固酮的浓度下，这5种α-还原代谢物也可以重现幼年肾上腺切除自发性高血压大鼠的高血压发展过程，并抑制血浆肾素活性。因此，几种代谢转化的醛固酮衍生物可以与激素作用的生理调节和/或表达相关联。
Metabolism of aldosterone during the latent period prior to the action of the hormone may be of physiological importance. In the rat, liver metabolizes aldosterone in a sex-dependent manner; larger quantities of neutral polar and reduced aldosterone derivatives are found in male rat kidney; correlating with the larger physiological responses of male rats to aldosterone. The target tissues, mammalian kidney and toad urinary bladder, are also capable of metabolizing aldosterone in situ to neutral polar, 5 alpha- and 5 beta-reduced, and monosulfate derivatives. The 5 alpha-reduced metabolites possess significant antinatriuretic activity and are preferentially synthesized by rat kidney nuclei. The metabolic pathways leading to the synthesis of 5 alpha-reduced metabolites and their subsequent neutral polar derivatives appear to be regulated by dietary sodium and can be inhibited by antimineralocorticoids. At concentrations somewhat higher than aldosterone, these 5 alpha-reduced metabolites also can recreate the development of hypertension and suppress plasma renin activity in young adrenalectomized spontaneously hypertensive rats. Thus, several of the metabolically transformed aldosterone derivatives can be correlated with physiological regulation and/or expression of the actions of the hormone.