High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton
High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton
复制标题
神经毡蛋白和 tolloid 样 1 的高表达通过肌动蛋白细胞骨架的调节与上皮性卵巢癌的转移和不良生存相关
DOI：
10.1111/jcmm.15547
复制
发表时间：
2020-07-08
影响因子：
5.3
通讯作者：
Shi, Wenyu
中科院分区：
文献类型：
--
作者：
Xu, Yunzhao;Wang, Wei;Shi, Wenyu
神经纤毛蛋白和tolloid-like 1（NETO 1）在某些人类肿瘤中有异常表达。然而，NETO 1在上皮性卵巢癌（EOC）中的表达及其机制尚不清楚。在这项研究中，我们发现，与正常卵巢组织样本相比，EOC组织样本中NETO 1的表达更高，与总体生存率更差显著相关。此外，考克斯回归分析表明NETO 1与总生存率独立相关。NETO 1过表达通过调节肌动蛋白细胞骨架增强EOC细胞的体外迁移和侵袭能力。从机制上讲，沉默NETO 1降低了β-微管蛋白、F-肌动蛋白和KIF 2A的表达。总之，我们的研究结果表明NETO 1在EOC侵袭中的关键作用，旨在抑制其表达或活性的治疗可能会显着控制EOC生长，侵袭和转移扩散。
Abnormal expression of neuropilin and tolloid-like 1 (NETO1) has been detected in some human carcinomas. However, the expression of NETO1 and the underlying mechanism in epithelial ovarian cancer (EOC) remain unknown. In this study, we found that a higher NETO1 expression in EOC tissue samples compared to normal ovarian tissue samples was significantly correlated with worse overall survival. Additionally, Cox regression analysis suggested that NETO 1 was independently associated with overall survival. NETO1 overexpression enhanced the EOC cells' migration and invasion capability in vitro via regulation of actin cytoskeleton. Mechanistically, silencing NETO1 reduced the expression of beta-tubulin, F-actin and KIF2A. In conclusion, our results demonstrated the critical role of NETO1 in EOC invasion, and therapies aimed at inhibiting its expression or activity might significantly control EOC growth, invasion and metastatic dissemination.