Disruption of specific white matter tracts is associated with neurogenic lower urinary tract dysfunction in women with multiple sclerosis.
Disruption of specific white matter tracts is associated with neurogenic lower urinary tract dysfunction in women with multiple sclerosis.
复制标题
特定白质束的破坏与多发性硬化症女性的神经源性下尿路功能障碍有关。
DOI：
10.1002/nau.25075
复制
发表时间：
2023
影响因子：
2
通讯作者：
Khavari,Rose
中科院分区：
文献类型：
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作者：
Choksi,Darshil;Schott,Bradley;Tran,Khue;Jang,Ryan;Hasan,KhaderM;Lincoln,JohnA;Jalali,Ali;Karmonik,Christof;Salazar,Betsy;Khavari,Rose
目的确定特定的白色物质束（WMT）的破坏与神经源性下尿路功能障碍（NLUTD）的严重程度在两个独立的队列的妇女多发性硬化症（MS）和NLUTD.MethodsCohort 1由28名妇女与MS和NLUTD。验证队列包括10名MS和NLUTD女性。11名健康女性作为对照组。两个MS队列的参与者具有相同的入选和排除标准。MS队列和健康对照组均接受相同的临床评估和功能性MRI（fMRI）方案，但验证MS队列接受7 T fMRI扫描。涉及膀胱控制的15个WMT（6个通向相关脑干区域）是先验感兴趣区域（ROI）。斯皮尔曼的相关性检验之间进行的每一个分数各向异性（FA）和平均扩散率（MD）的每个WMT和临床parameters.ResultsOverall，我们发现了一个非常高的重叠程度（100%的先验投资回报率）在我们的相关性分析确定为具有最大的贡献NLUTD症状MS妇女的道。右下小脑脚，左后囊膜，左上级小脑脚显示显着的协会最大数量的临床parameters.ConclusionsOur相关性分析支持特定的WMT中断的作用，在MS和NLUTD的妇女的症状的贡献，证实在两个独立的MS队列。
ObjectiveTo identify specific white matter tracts (WMTs) whose disruption is associated with the severity of neurogenic lower urinary tract dysfunction (NLUTD) in two independent cohorts of women with multiple sclerosis (MS) and NLUTD.MethodsCohort 1 consisted of twenty‐eight women with MS and NLUTD. The validation cohort consisted of 10 women with MS and NLUTD. Eleven healthy women served as controls. Participants of both MS cohorts had the same inclusion and exclusion criteria. Both MS cohorts and the healthy controls underwent the same clinical assessment and functional MRI (fMRI) protocol, except that the validation MS cohort underwent 7‐Tesla fMRI scan. Fifteen WMTs (six coursing to relevant brainstem areas) involved in bladder control were a priori regions of interest (ROI). Spearman's correlation test was performed between each the Fractional Anisotropy (FA) and mean diffusivity (MD) of each WMT and the clinical parameters.ResultsOverall, we found a very high degree of overlap (100% of a priori ROI) in the tracts identified by our correlation analysis as having the greatest contribution to NLUTD symptoms in MS women. The right inferior cerebellar peduncle, left posterior limb of internal capsule, and left superior cerebellar peduncle displayed significant associations to the greatest number of clinical parameters.ConclusionsOur correlation analysis supports the role of specific WMT disruptions in the contribution of symptoms in women with MS and NLUTD, as confirmed in two independent MS cohorts.