More inclusive research is needed for an equitable response to dementia.
More inclusive research is needed for an equitable response to dementia.
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DOI：
10.1016/j.lanepe.2022.100329
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Katikireddi SV
中科院分区：
文献类型：
--
作者：
Amele S;Katikireddi SV
痴呆症影响着全球约5500万人，目前是第七大死亡原因，尽管未来几年它无疑会进一步增长。2020年柳叶刀委员会确定了12个可改变的风险因素，可以有针对性地预防或延迟痴呆症，其中许多在社会弱势群体中更为常见。2然而，卫生研究仍然往往代表少数民族群体和社会经济最弱势的人。在英国，这意味着研究主要包括来自富裕背景的白色个体，对种族和其他社会因素对痴呆症的影响知之甚少。Bothongo及其同事最近发表在《柳叶刀区域卫生欧洲》上的论文描述了种族、区域水平剥夺和痴呆症之间的联系。3他们利用东伦敦四个行政区的初级保健数据进行了嵌套匹配病例对照研究。3通过利用电子健康记录的力量，他们能够确保少数民族群体和生活在最贫困地区的人被包括在内。3根据作者的说法，这是第一项描述英国南亚人患痴呆症风险的研究，并表明与生活在同一地区的白色人群相比，这一人群亚组的风险增加。3他们发现种族和地区水平的剥夺与痴呆症独立相关。黑人和南亚种族的个体患痴呆症的风险更高（比值比[OR]：1.43，95% CI：1.31 - 1.56和1.17，95% CI：1.06 - 1.29）。然而，他们没有发现证据表明已知的痴呆症可改变的风险因素解释了这些差异，因此作者认为，针对与种族和贫困相关的因素进行干预比可改变的风险因素更重要。3作者强调了潜力
Dementia affects an estimated 55 million individuals globally and is currently the seventh leading cause of death, although it will undoubtedly grow further over coming years. 1 The 2020 Lancet Commission identified 12 modifiable risk factors that can be targeted to prevent or delay dementia, many of which are more common among socially disadvantaged groups. 2 However, health research still too often under-represents people from minoritised ethnic groups and the most socioeconomically disadvantaged. In the UK this has meant studies predominately include White individuals from affluent backgrounds, with less known about the impact of ethnicity and other social factors on dementia. The recent paper by Bothongo and colleagues published in The Lancet Regional Heath-Europe describes the association between ethnicity, area-level deprivation, and dementia. 3 They carried out a nested matched casecontrol studying using primary care health data from four East London boroughs. 3 By harnessing the power of electronic health records, they were able to ensure individuals from minoritised ethnic groups and people living in the most deprived areas were included. 3 According to the authors, this is the first study to describe the risk of dementia among South Asians in the UK, and showed that this population subgroup have an increased risk compared to the White population living in the same area. 3They found that both ethnicity and area-level deprivation were independently associated with dementia. Individuals of Black and South Asian ethnicity had a higher risk of dementia (odds ratio [OR]: 1.43, 95% CI: 1.31− 1.56 and 1.17 95% CI: 1.06− 1.29, respectively). 3 However, they did not find evidence to suggest that the known modifiable risk factors for dementia explained these differences, and therefore the authors suggest it is more important to target interventions at factors associated with ethnicity and deprivation than the modifiable risk factors. 3 The authors highlight the potential
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影响因子：
6.3
作者：
Katikireddi SV;Lal S;Carrol ED;Niedzwiedz CL;Khunti K;Dundas R;Diderichsen F;Barr B
通讯作者：
Barr B
影响因子：
15.1
作者：
Osuafor CN;Golubic R;Ray S
通讯作者：
Ray S
DOI：
10.1002/dad2.12067
发表时间：
2020-01-01
影响因子：
5.3
作者：
Coogan, Patricia;Schon, Karin;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn
影响因子：
14.5
作者：
Brayne, Carol;Ince, Paul G.;Sulkava, Raimo
通讯作者：
Sulkava, Raimo