Delayed evoked potentials in children exposed to methylmercury from seafood
Delayed evoked potentials in children exposed to methylmercury from seafood
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DOI：
10.1016/s0892-0362(99)00011-2
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发表时间：
1999-07-01
影响因子：
2.9
通讯作者：
Grandjean, P
中科院分区：
文献类型：
--
作者：
Murata, K;Weihe, P;Grandjean, P
甲基汞中毒可能会导致视野缩小和耳聋，特别是在产前接触甲基汞中毒时。然而，与接触受污染海鲜相关的风险尚不清楚。我们对马德拉渔业社区的 149 名一年级儿童进行了检查。由于母亲的饮食习惯相对没有变化，目前的母亲头发浓度被用作孩子产前甲基汞暴露的指标（几何平均值，9.64 μg/g [48.2 nmol/g]）。调整年龄和性别后，当母亲头发汞浓度超过 10 μg/g (50 nmol/g) 时，40 Hz 时脑干听觉诱发电位峰值 III 的平均 (+/- SD) 潜伏期增加 0.128 +/- 0.047 ms（关联 p，0.002），并且 15 分钟时 N145 模式反转视觉诱发电位潜伏期的增加为3.16 +/- 1.57 ms（关联 p，0.002）。没有发现这种与孩子自身头发汞浓度的关系，其他临床检查也没有发现与汞相关的缺陷。对大脑功能产生不利影响的神经生理学证据相对独立于混杂因素，在这种海鲜污染物的风险评估中应予以考虑。 (C) 1999 Elsevier Science Inc. 保留所有权利。
Methylmercury poisoning may cause constriction of visual fields and deafness, especially if exposure occurs prenatally. However, the risks associated with exposure from contaminated seafood is unclear. We examined 149 children attending first grade in a Madeiran fishing community. As maternal dietary habits were relatively unchanged, current maternal hair concentrations were used as indicator of the child's prenatal exposure to methylmercury (geometric average, 9.64 mu g/g [48.2 nmol/g]). After adjustment for age and sex, the mean (+/- SD) latency of peak III of the brainstem auditory evoked potentials at 40 Hz was increased by 0.128 +/- 0.047 ms when maternal hair-mercury concentrations exceeded 10 mu g/g (50 nmol/g) (p for association, 0.002), and the increase of the N145 pattern-reversal Visual evoked potential latency at 15 minutes of are was 3.16 +/- 1.57 ms (p for association, 0.002). No such relationships were seen with the child's own hair-mercury concentration, and other clinical examinations revealed no mercury-associated deficits. Neurophysiological evidence of adverse effects on brain function are relatively independent of confounders, and should be considered in the risk assessment of this seafood pollutant. (C) 1999 Elsevier Science Inc. All rights reserved.