THE DISTRIBUTION OF MERKEL CELLS IN HUMAN FETAL AND ADULT SKIN
THE DISTRIBUTION OF MERKEL CELLS IN HUMAN FETAL AND ADULT SKIN
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DOI：
10.1097/00000372-199210000-00003
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发表时间：
1992-10-01
影响因子：
1.1
通讯作者：
WALSH, N
中科院分区：
文献类型：
--
作者：
BOOT, PM;ROWDEN, G;WALSH, N
默克尔细胞（MC）已经在人类和动物研究中研究了超过世纪，但是它们的起源、功能和在人类皮肤中的确切分布仍然在很大程度上未知。本研究的目的是量化这些皮肤神经内分泌细胞在胎儿和成人皮肤，使用免疫组织化学标记（神经元特异性烯醇化酶）和形态学方法。我们的结果表明。出生后MC沿表皮下表面沿着分布，偶见附件上皮，基底层每厘米约0.1-1.0 MC。它们在掌侧皮肤上数量最多，在生殖器皮肤上数量最少，在面部，它们主要分布在毛囊周围。胎儿样本显示，MC出现在妊娠第15周和第18周之间，并且在掌侧皮肤上最丰富。它们似乎出现在表皮内，最初数量众多，后来随着胎龄的增加而减少。它们在宫内生活中的优势表明在生长和发育中的功能作用。
Merkel cells (MCs) have been a subject of investigation in human and animal studies for over a century, but their origin, function(s), and exact distribution in human skin remain largely unknown. The objectives of the present study were to quantify these cutaneous neuroendocrine cells in fetal and adult human skin, using an immunohistochemical marker (neuron-specific enolase) and morphometric methods. Our results indicate. that, in postnatal life, MC are sparsely distributed along the undersurface of epidermal and occasionally adnexal epithelium in an approximate range of 0.1-1.0 MCs per centimeter of basal zone. They are most numerous on volar skin and least on genital skin, and on the face they have a primarily perifollicular orientation. Fetal samples have shown that MCs appear between the 15th and 18th week of gestation and are most abundant on volar skin. They appear to arise within the epidermis, and are initially numerous and later diminish with increasing gestational age. Their predominance in intrauterine life suggests a functional role in growth and development.