A Highly Active PN3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditions
A Highly Active PN3 Manganese Pincer Complex Performing N-Alkylation of Amines under Mild Conditions
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DOI：
10.1021/acs.orglett.9b00832
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发表时间：
2019-05-03
期刊：
影响因子：
5.2
通讯作者：
Hultzsch, Kai C.
中科院分区：
文献类型：
--
作者：
Homberg, Leonard;Roller, Alexander;Hultzsch, Kai C.
报道了一种基于非对称PN3配体骨架的高活性Mn(I)催化剂，用于胺与醇的N-烷基化反应。一系列的苯胺和更具挑战性的脂肪胺与伯醇和仲醇发生烷基化反应。此外，低催化剂负载量和温和的反应条件相结合，为这种原子经济转化提供了高效率。
A highly active Mn(I) catalyst based on a nonsymmetric PN3-ligand scaffold for the N-alkylation of amines with alcohols utilizing the borrowing hydrogen methodology is reported. A broad range of anilines and the more challenging aliphatic amines were alkylated with primary and secondary alcohols. Moreover, the combination of low catalyst loadings and mild reaction conditions provides high efficiency for this atom-economic transformation.