Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat
Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat
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DOI：
10.1016/s0006-8993(98)00602-7
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发表时间：
1998-08-17
期刊：
影响因子：
2.9
通讯作者：
Levine, AS
中科院分区：
文献类型：
--
作者：
Giraudo, SQ;Kotz, CM;Levine, AS
杏仁核中央核（CNA）和孤立束核（NTS）在摄食行为的调节中起重要作用。我们评估了中枢和吻侧NTS （rNTS）之间的阿片-阿片信号是否影响摄食行为。为了验证这一点，大鼠被双重插管，一根插管在rNTS，一根插管在CNA，允许在一个部位同时施用阿片受体激动剂，在另一个部位同时施用阿片拮抗剂。将2 nmol的Tyr-D-Ala-Gly-(me) ph - gly -ol （DAMGO）注射到CNA （CNA DAMGO）中，使大鼠的进食量增加了2倍以上。当向rNTS注射26.5和79 nmol的纳曲酮（NTX）时，这种食物摄入的增加被阻止了。在相反的情况下，当给药剂量为26.5和79 nmol时，rNTS DAMGO增加了高于对照水平的食物摄入量，CNA NTX阻断了DAMGO诱导的进食。这表明在CNA和rNTS之间存在一个双向的阿片-阿片信号通路，通过多阿片受体影响摄食。(C) 1998 Elsevier Science B.V.版权所有
The central nucleus of the amygdala (CNA) and the nucleus of the solitary tract (NTS) are important in the regulation of ingestive behavior. We evaluated whether opioid-opioid signaling between the CNA and rostral NTS (rNTS) affect feeding behavior. To test this, rats were doubly cannulated with one cannula placed in the rNTS and one cannula in the CNA, allowing for co-administration of an opioid agonist into one site and an opioid antagonist into the other. Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO) (2 nmol) injected into the CNA (CNA DAMGO) increased feeding more than two-fold compared to the vehicle-injected rats. This increase in food intake was blocked when doses of 26.5 and 79 nmol of naltrexone (NTX) were injected into the rNTS. In the reverse situation, rNTS DAMGO increased food intake above control levels, and CNA NTX blocked DAMGO-induced feeding when administrated in doses of 26.5 and 79 nmol. This suggests that a bi-directional opioid-opioid signaling pathway exists between the CNA and the rNTS which influences feeding via mu-opioid receptors. (C) 1998 Elsevier Science B.V. All rights reserved.