Effect of systemic hypertension on foveolar choroidal blood flow in age related macular degeneration
Effect of systemic hypertension on foveolar choroidal blood flow in age related macular degeneration
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DOI：
10.1136/bjo.2005.082974
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发表时间：
2006-03-01
影响因子：
4.1
通讯作者：
Ying, GS
中科院分区：
文献类型：
--
作者：
Metelitsina, TI;Grunwald, JE;Ying, GS
目的：目的：探讨老年性黄斑变性（AMD）患者高血压（SH）对黄斑中心凹脉络膜循环的影响。研究眼的视力为20/40或更好，玻璃疣>= 63 mm，和/或RPE肥大。56名AMD患者有SH病史，其中47名患者正在接受降压药物治疗。使用激光多普勒血流仪（Oculix）评估研究眼中心凹的相对脉络膜血流速度（ChBVel）、体积（ChBVel）和流量（ChBFlow）。使用方差分析（ANOVA）和线性趋势检验，调整同一patient.Results的眼睛之间的相关性，评估各组之间的平均血液动力学参数的差异：AMD患者SH显示ChBFlow降低与那些没有SH（ANOVA，p = 0.02）。在调整多个因素后，这种相关性仍保持不变（p = 0.04）。结论：合并SH的AMD患者的ChBFlow低于不合并SH的患者。脉络膜血液循环的减少可能有助于解释全身性高血压可能导致AMD进展和脉络膜新生血管形成的机制。
Aim: To investigate the effect of systemic hypertension (SH) on the foveolar choroidal circulation in patients with age related macular degeneration (AMD).Methods: This study included 163 study eyes with early AMD characteristics of 124 AMD patients. Study eyes had visual acuity of 20/40 or better, drusen >= 63 mm, and/or RPE hypertrophy. 56 of the AMD patients had a history of SH and 47 of these patients were receiving antihypertensive medications. Laser Doppler flowmetry (Oculix) was used to assess relative choroidal blood velocity (ChBVel), volume (ChBVol), and flow (ChBFlow) in the centre of the fovea of the study eyes. Differences in the mean haemodynamic parameters between groups of eyes were assessed using analysis of variance (ANOVA) and a test of linear trend, with adjustment for the correlation between eyes of the same patient.Results: AMD patients with SH showed decreased ChBFlow in comparison with those without SH (ANOVA, p = 0.02). This association was maintained after adjustments for multiple factors (p = 0.04).Conclusions: AMD patients with SH have lower ChBFlow than those without SH. This decrease in choroidal blood circulation may help explain the mechanism by which systemic hypertension may contribute to the progression of AMD and the development of choroidal neovascularisation.