Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
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DOI：
10.1073/pnas.181340798
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发表时间：
2001-09-11
影响因子：
11.1
通讯作者：
Black, PM
中科院分区：
文献类型：
--
作者：
Lu, QR;Park, JK;Black, PM
人脑最常见的原发性肿瘤被认为是胶质细胞起源的。然而，神经胶质细胞肿瘤不能通过细胞形态或星形胶质细胞、少突胶质细胞或其祖细胞的常规标记物进行完全分类。最近对中枢神经系统肿瘤发生的见解表明，可能会在神经胶质发育中起作用的因素中发现新的分子标记。少突胶质细胞谱系基因 (Olig1/2) 编码基本螺旋-环-螺旋转录因子。在啮齿动物中枢神经系统中，它们仅在少突胶质细胞和少突胶质细胞祖细胞中表达，并且Olig1可以促进硫酸软骨素蛋白糖阳性神经胶质祖细胞的形成。在这里，我们发现人类 OLIG 基因在少突胶质细胞瘤中强烈表达，相比之下在星形细胞瘤中不表达或低表达。我们的数据提供的证据表明，少突胶质细胞瘤的肿瘤细胞类似于少突胶质细胞或其祖细胞，并且可能源自该谱系的细胞。他们进一步表明 OLIG 标记物在增强少突胶质细胞肿瘤识别方面的诊断潜力。
The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Recent insights into central nervous system tumorigenesis suggest that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig1/2)encode basic helix-loop-helix transcription factors. In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor. Here we show that human OLIG genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Our data provide evidence that neoplastic cells of oligodendroglioma resemble oligodendrocytes or their progenitor cells and may derive from cells of this lineage. They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors.