WWP2 Is One Promising Novel Oncogene
WWP2 Is One Promising Novel Oncogene
复制标题
DOI：
10.1007/s12253-018-0506-5
复制
发表时间：
2018-11
影响因子：
2.8
通讯作者：
Rui Zhang;Jianwu Zhang;W. Luo;Zhuang Luo;Shaoqing Shi
中科院分区：
文献类型：
--
作者：
Rui Zhang;Jianwu Zhang;W. Luo;Zhuang Luo;Shaoqing Shi
WWP2 是一种 E3 泛素连接酶，通过其底物的泛素化和降解在许多细胞生物活性的调节中发挥重要作用。最近越来越多的证据表明WWP2在不同类型肿瘤的发病机制中发挥着至关重要的作用。在本报告中，回顾了该基因特别是在肿瘤发生中的作用。 WWP2在多种肿瘤中失调，主要通过PTEN/Akt信号通路促进癌变。 WWP2 还参与抗癌药物的敏感性，表明 WWP2 可能是癌症治疗的新靶点。 WWP2 是一种有前途的新型癌基因。
WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors. In this report, the role of this gene especially in tumorigenesis was reviewed. WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents’ sensitivity, indicating WWP2 may be a novel target for cancer treatment. WWP2 is one promising novel oncogene.