Monitoring Water Content of Blood During Hemodialysis Based on Complex Permittivity Measurement
Monitoring Water Content of Blood During Hemodialysis Based on Complex Permittivity Measurement
复制标题
基于复介电常数测量的血液透析过程中血液含水量监测
DOI：
10.1109/jsen.2020.2978220
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发表时间：
2020-07
影响因子：
4.3
通讯作者：
Wang Jianqing
中科院分区：
文献类型：
--
作者：
Shi Jingjing;Seo Shinnosuke;Wang Jianqing
在血液透析治疗中，需要准确掌握血液中废物的量和水的量。实时监测血液含水量，可以有效设定合适的透析时间，减轻血液透析患者的负担。在本研究中，我们提出了一种基于 Lichtenecker 指数定律的血液含水量监测方法，使用网络分析仪和开放式同轴探头进行复介电常数表达和测量。 Lichtenecker关于含水量的指数定律表达式是一种新的尝试。为了验证其有效性，我们首先将该方法应用于不同含水量的苹果汁和葡萄糖水溶液。估算的含水量与实际含水量的相对误差在9%以内，保证了该方法的有效性。然后我们应用该方法对18名血液透析患者透析期间的血液含水量进行了监测。结果显示，所有血液透析患者的水含量均通过透析明显降低。透析后，预计血液含水量均在35%至45%之间，基本落在正常血液含水量范围内，接近一半。此外，我们还研究了血液中的含水量与血细胞比容之间的关系，发现它们之间存在很强的相关系数，为-0.8。结果证明了基于复介电常数测量来监测透析期间血液含水量以及血细胞比容或贫血状态的可行性。
In hemodialysis treatment, it is necessary to accurately grasp the amount of waste products and the amounts of water in the blood. Real time monitoring of the water content of blood is effective for setting an appropriate dialysis time and thus reduce the burden on hemodialysis patients. In this study, we proposed a monitoring method of water content of blood based on Lichtenecker’s exponential law for complex permittivity expression and measurement using a network analyzer and an open-ended coaxial probe. The Lichtenecker’s exponential law expression in relation to the water content is a new attempt. To verify its validity, we first applied this method to apple juice with varying water content and aqueous solutions of glucose. The estimated water contents showed a relative error within 9% of actual ones, which ensured the validity of the proposed method. Then we applied this method to monitor the water content of blood during dialysis for 18 hemodialysis patients. The results showed a clear decrease of water content by dialysis for all hemodialysis patients. After dialysis, the estimated water contents of the blood were all between 35% and 45%, essentially falling in the normal range of water content of blood, nearly half. In addition, we also investigated the relationship between the water content and hematocrit in the blood, and found a strong correlation coefficient of −0.8 between them. The results demonstrated the feasibility to monitor the water content of blood during dialysis as well as hematocrit or anemia state based on the complex permittivity measurement.
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影响因子：
1.9
作者：
Masakane, Ikuto;Nakai, Shigeru;Nitta, Kosaku
通讯作者：
Nitta, Kosaku
DOI：
10.1109/memb.2010.936554
发表时间：
2010-05-01
影响因子：
--
作者：
Bonato, Paolo
通讯作者：
Bonato, Paolo
DOI：
10.1109/tmtt.2003.809626
发表时间：
2003-04-01
影响因子：
4.3
作者：
Hagl, DA;Popovic, D;Okoniewski, M
通讯作者：
Okoniewski, M
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
P. Bonato
通讯作者：
P. Bonato
影响因子：
--
作者：
Akira Takeda;K. Takata;Hirotomo Nagao;Jianqing Wang;O. Fujiwara
通讯作者：
Akira Takeda;K. Takata;Hirotomo Nagao;Jianqing Wang;O. Fujiwara