Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22.
Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22.
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DOI：
10.1038/jid.2008.297
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发表时间：
2009-03
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影响因子：
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已知银屑病的易感性受人类白细胞抗原C、白介素12B和白介素23R基因变异的影响，尽管已经发现了其他与银屑病相关的变异体，但这些标记物的统计证据是不容置疑的。为了帮助解决这个问题，我们在1,448名银屑病患者和1,385名对照受试者中，从7个可能的银屑病危险基因中检测了15个单核苷酸多态(SNPs)；ADAM33中的rs597980、CDKAL1中的rs6908425和PTPN22中的rs3789604具有与先前报道相同的风险等位基因(单侧P<；0.05，错误发现率为0.15)。这三个标记在第四个样本集(599个病例和299个对照)中进行了测试；一个标记rs597980重复(单侧P<；0.05)，另外两个具有与原始样本集相同方向性的优势比。MANTEL-Haenszel Meta分析显示，这三个标记具有高度显著性(rs597980：P=0.0057(2,025例病例和1,597例对照)，rs6908425：P=1.57×10−5(3,206例病例和4,529例对照)；rs3789604：P=3.45×10−5(2,823例病例和4,066例对照))。这些数据增加了ADAM33、CDKAL1和PTPN22是真正的银屑病风险基因的可能性。
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained. To help resolve this issue, we tested 15 single-nucleotide polymorphisms (SNPs) from 7 putative psoriasis-risk genes in 1,448 psoriasis patients and 1,385 control subjects; 3 SNPs, rs597980 in ADAM33, rs6908425 in CDKAL1 and rs3789604 in PTPN22, were significant with the same risk allele as in prior reports (one-sided P<0.05, false discovery rate<0.15). These three markers were tested in a fourth sample set (599 cases and 299 controls); one marker, rs597980, replicated (one-sided P<0.05) and the other two had odds ratios with the same directionality as in the original sample sets. Mantel–Haenszel meta-analyses of all available case–control data, including those published by other groups, showed that these three markers were highly significant (rs597980: P =0.0057 (2,025 cases and 1,597 controls), rs6908425: P =1.57×10−5 (3,206 cases and 4,529 controls), and rs3789604: P =3.45×10−5 (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes.
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影响因子：
3.5
作者：
Li Y;Chang M;Schrodi SJ;Callis-Duffin KP;Matsunami N;Civello D;Bui N;Catanese JJ;Leppert MF;Krueger GG;Begovich AB
通讯作者：
Begovich AB
影响因子：
9.8
作者：
Nair, RP;Stuart, PE;Elder, JT
通讯作者：
Elder, JT
影响因子：
56.9
作者：
Duerr, Richard H.;Taylor, Kent D.;Cho, Judy H.
通讯作者：
Cho, Judy H.
影响因子：
9.8
作者：
Cargill, Michele;Schrodi, Steven J.;Begovich, Ann B.
通讯作者：
Begovich, Ann B.
PTPN22区域中的多态性与早期发作的牛皮癣有关。
影响因子：
10.3
作者：
Smith, Rh. Ll.;Warren, R. B.;Eyre, S.;Ke, X.;Young, H. S.;Allen, M.;Strachan, D.;McArdle, W.;Gittins, M. P.;Barker, J. N. W. N.;Griffths, C. E. M.;Worthington, J.
通讯作者：
Worthington, J.