Helminth infections are associated with protection from malaria-related acute renal failure and jaundice in Thailand
Helminth infections are associated with protection from malaria-related acute renal failure and jaundice in Thailand
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DOI：
10.4269/ajtmh.2001.65.834
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
Looareesuwan, S
中科院分区：
文献类型：
--
作者：
Nacher, M;Singhasivanon, P;Looareesuwan, S
在研究显示蠕虫感染和脑型疟疾保护之间的关联后，我们比较了22例疟疾相关急性肾功能衰竭患者和157例中重度疟疾患者。蠕虫与肾功能衰竭保护相关（校正比值比[AOR]，0.16 [0.03-0.85]，P = 0.03）。与无蠕虫的对照组相比，蠕虫感染的对照组出现黄疸（AOR，0.39 [0.16-0.96]，P = 0.04）或外周成熟寄生虫（AOR，0.2 [0.07-0.62]，P = 0.005）的可能性较小。这表明，预先存在的蠕虫感染可能通过影响隔离和阻塞性黄疸（急性肾小管坏死的两个可能决定因素）而具有保护作用。
Following studies showing an association between helminth infections and protection from cerebral malaria, we compared 22 patients with malaria-associated acute renal failure with 157 patients with moderately severe malaria. Helminths were associated with protection from renal failure (adjusted odds ratio [AOR], 0.16 [0.03-0.85], P = 0.03). Helminth-infected controls were less likely to have jaundice (AOR, 0.39 [0.16-0.96], P = 0.04) or to have peripheral mature schizonts (AOR, 0.2 [0.07-0.62], P = 0.005) than controls without helminths. This suggested that preexisting helminth infections may have been protective by influencing sequestration and obstructive jaundice, 2 possible determinants of acute tubular necrosis.