Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system.
Amniogenic somatopleure: a novel origin of multiple cell lineages contributing to the cardiovascular system.
复制标题
羊膜源性躯体：多个细胞谱系的新起源，导致心血管系统。
DOI：
10.1038/s41598-017-08305-2
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发表时间：
2017-08-21
影响因子：
4.6
通讯作者：
Kurihara H
中科院分区：
文献类型：
--
作者：
Asai R;Haneda Y;Seya D;Arima Y;Fukuda K;Kurihara Y;Miyagawa-Tomita S;Kurihara H
体侧板是羊膜原基在胚胎发育，但其边界的胚胎体在早期胚胎阶段和细胞的命运构成这个结构没有得到很好的表征。目前还不清楚细胞在胚胎内和胚胎外组织之间的分界过程中是如何表现的。在这里，我们确定细胞的路线，这表明两个流向的网站背羊膜关闭和腹侧胸壁的形成。中胚层细胞的亚群从邻近头褶基部的体侧区向腹侧移动进入胚胎的身体并分布到胸壁、咽弓和心脏。这些细胞可能分别通过FGF和BMP信号传导被诱导分化为血管内皮细胞和心肌细胞。这些结果表明，体侧板作为羊膜原基也作为胚胎细胞的来源，这可能有助于心血管发育。
The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during the demarcation between intra- and extra-embryonic tissues. Here we identify cellular alignments, which indicate two streams towards the sites of dorsal amniotic closure and ventral thoracic wall formation. A subpopulation of mesodermal cells moving ventrally from the somatopleural region adjacent to the base of the head fold enter the body of the embryo and distribute to the thoracic wall, pharyngeal arches and heart. These cells are induced to differentiate into vascular endothelial cells and cardiomyocytes possibly by FGF and BMP signaling, respectively. These results indicate that the somatopleure acting as the amniotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular development.