Flexible Eectrostatic Hydrogels from Marine Organism for Nitric Oxide-Enhanced Photodynamic Therapy Against Multidrug-Resistant Bacterial Infection
Flexible Eectrostatic Hydrogels from Marine Organism for Nitric Oxide-Enhanced Photodynamic Therapy Against Multidrug-Resistant Bacterial Infection
复制标题
来自海洋生物的柔性静电水凝胶用于一氧化氮增强光动力疗法对抗多重耐药细菌感染
DOI：
10.1007/s40843-022-2024-6
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fu-Jian Xu
中科院分区：
文献类型：
--
作者：
Yujie Sun;Rong-Lai Wen;Dan Yu;Yiwen Zhu;Liang Zheng;Xiangdong Liu;Haoran Wang;Bingran Yu;Fu-Jian Xu
The abuse of antibiotics in treating microbial infections has led to the emergence and prevalence of drug-resistant bacteria. Thus, the development of novel antibacterial materials is attracting increasing attention. Here, a series of flexible electrostatic hydrogels with excellent antibacterial ability were constructed using a mixture of nitric oxide (NO)-releasing nitrated chitosan (CSNO) and mesotetra(4-carboxyphenyl)porphine (TCPP) with salmon sperm DNA (ssDNA) solution. When cultured with gram-negative bacteria under solar simulator irradiation, TCPP-CSNOm-ssDNAnhydrogels released reactive oxygen species (ROS) and NO to produce peroxynitrite ions (ONOO−). ONOO−is efficient at killing bacteria, thereby improving the antimicrobial ability of photodynamic therapy against gram-negative bacteria. The hydrogels exhibited powerful antibacterial activityin vivowhen used to treat skin infections caused by drug-resistant bacteria, making them a promising candidate for clinical applications. A string of antibacterial hydrogels that release ROS and NO synergistically can bring new possibilities for effectively killing drug-resistant bacteria and be of great value in anti-infection wound dressings and other applications.
