Plasmalogens: targets for oxidants and major lipophilic antioxidants
Plasmalogens: targets for oxidants and major lipophilic antioxidants
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DOI：
10.1042/bst0320147
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发表时间：
2004-02-01
影响因子：
3.9
通讯作者：
Engelmann, B
中科院分区：
文献类型：
--
作者：
Engelmann, B
细胞膜和血浆脂蛋白对氧化应激的保护作用不如哺乳动物生物体的各种水舱有效。在这里，先前关于血浆原在脂质氧化中的作用的结果是根据抗氧化剂所需的标准进行评估的。血浆Logen特有的烯醇醚双键是各种氧化剂的靶标，包括过氧基、金属离子、单线态氧和卤化物种。乙烯基醚的氧化显著地防止了高度多不饱和脂肪酸的氧化，并且纤溶酶原降解的产物不会促进脂质氧化。这种保护作用也在分子内得到证实，从而确定了血浆原作为多不饱和脂肪酸的主要储存池的功能。尽管细胞迅速整合和合成血浆原，但它们的血浆原含量可以通过补充前体而故意增加。因此，血浆原终止脂质氧化过程，以足够的浓度出现在适当的位置，并迅速再生，在体外将它们归类为有效的抗氧化剂。未来的工作应解决体内血浆蛋白原在脂质氧化中的作用以及血浆蛋白原与氧化剂相互作用的生物学功能。
Cellular membranes and plasma lipoproteins are less efficiently protected against oxidative stress than the various aqueous compartments of mammalian organisms. Here, previous results on the role of plasmalogens in lipid oxidation are evaluated on the basis of criteria required for an antioxidant. The plasma logen-specific enol ether double bond is targeted by a vast variety of oxidants, including peroxyl radicals, metal ions, singlet oxygen and halogenating species. Oxidation of the vinyl ether markedly prevents the oxidation of highly polyunsaturated fatty acids, and products of plasmalogen degradation do not propagate lipid oxidation. This protection is also demonstrated intramolecularly, thus ascertaining the function of plasmalogens as a major storage pool for polyunsaturated fatty acids. Although cells rapidly incorporate and synthesize plasmalogens de novo, their plasmalogen contents can be deliberately increased by supplementation with precursors. Thus plasmalogens terminate lipid-oxidation processes, are present in adequate locations at sufficient concentrations, and are rapidly regenerated, classifying them as efficient antioxidants in vitro. Future work should address the in vivo role of plasmalogens in lipid oxidation and the biological function of plasmalogen interactions with oxidants.