Hemodynamic changes in rats after opening an arteriovenous fistula.
Hemodynamic changes in rats after opening an arteriovenous fistula.
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打开动静脉内瘘后大鼠血流动力学的变化。
DOI：
10.1152/ajpheart.1992.262.3.h846
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Guyton,AC
中科院分区：
文献类型：
--
作者：
Huang,M;Hester,RL;Guyton,AC
评估了大鼠打开动静脉瘘后多种血流动力学变化的时间过程。在雄性Sprague-Dawley大鼠中，通过闭合肾动脉下方的主动脉和腔静脉来制作瘘。在假手术对照组或动静脉瘘开放后1 h（1H）、1 d（1D）、1 wk（1 W）和5 wk（5 W），我们使用放射性微球测量心输出量（CO）和组织流量。微球到肺的流量被用作分流流量的量度。在瘘管动物中，该肺流量（瘘管流量）为CO的50-77%，而对照动物为1-3%。与连续时间组的相应对照动物相比，瘘管动物的心脏指数增加了40、107、129和307%。1H和1 W组瘘管动物的体循环流量、组织流量和平均动脉血压（MAP）显著降低至对照值以下，但这些变量在5 W后均恢复至对照水平。红细胞压积（Hct）显着下降，而右心房压力（RAP）逐渐增加，在实验期间。这两个观察结果表明液体潴留。血浆肾素活性在1H动物中增加，但在1D动物中恢复到对照组。心钠素（ANP）在5周内逐渐升高，从86 +/- 22（1H）至709 +/- 217 pg/ml（5 W）。ANP的增加与RAP的增加相关。在整个实验过程中，瘘管动物的计算总外周阻力显著降低。（250字处删节）
Time course of multiple hemodynamic changes in rats after opening an AV fistula was assessed. The fistula was made in male Sprague-Dawley rats by anastomosing the aorta and vena cava below the renal arteries. At 1 h (1H), 1 day (1D), 1 wk (1W) and 5 wk (5W) in sham controls or after opening an AV fistula, we measured cardiac output (CO) and tissue flows by using radioactive microspheres. The flow of microspheres to the lungs was used as a measure of shunt flow. In the fistula animals this lung flow (fistula flow) was 50-77% of the CO compared with 1-3% in the control animals. Cardiac index in the fistula animals increased by 40, 107, 129, and 307% compared with the respective control animals in the consecutive time groups. Systemic flow, tissue flows, and mean arterial blood pressure (MAP) in the fistula animals in the 1H and 1W groups were significantly decreased below control values, but each of these variables returned to control levels after 5W. Hematocrit (Hct) significantly decreased, whereas right atrial pressure (RAP) gradually increased over the experimental period. These two observations suggest retention of fluid. Plasma renin activity increased in the 1H animals but returned to control in the 1D animals. Atrial natriuretic peptide (ANP) gradually increased throughout the 5 wk from 86 +/- 22 (1H) to 709 +/- 217 pg/ml (5W). The increase in ANP correlated with the increase in RAP. Calculated total peripheral resistance in fistula animals was significantly decreased throughout the experiments.(ABSTRACT TRUNCATED AT 250 WORDS)