Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin
Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin
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DOI：
10.1021/jf034132y
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发表时间：
2003-06-04
影响因子：
6.1
通讯作者：
Hirayama, M
中科院分区：
文献类型：
--
作者：
Matsumoto, H;Nakamura, Y;Hirayama, M
花青素被认为可以改善视觉功能。研究了黑加仑果实中的四种花色苷对青蛙杆状外节(ROS)膜再生视紫红质的影响。花青素3-糖苷、糖苷和芦丁糖苷对再生有促进作用，而相应的飞蝶素对再生无明显影响。氰基3-芦丁糖苷可加速再生中间体的形成。还研究了它们对ROS膜中cGMP-磷酸二酯酶活性的影响，但可忽略不计。结论：杆状感光器中的花青素主要作用于视紫红质的再生。
Anthocyanins have been suggested to improve visual functions. This study examined the effect of four anthocyanins in black currant fruits on the regeneration of rhodopsin using frog rod outer segment (ROS) membranes. Cyanidin 3-glycosides, glucoside and rutinoside, stimulated the regeneration, but the corresponding delphinidins showed no significant effect. The formation of a regeneration intermediate was suggested to be accelerated by cyanidin 3-rutinoside. Their effects on the cGMP-phosphodiesterase activity in the ROS membranes were also investigated but found to be negligible. It was concluded that the major effect of anthocyanins in rod photoreceptors is on the regeneration of rhodopsin.