Functional-morphologic MR imaging with ultrasmall superparamagnetic particles of iron oxide in acute and chronic soft-tissue infection:: Study in rats
Functional-morphologic MR imaging with ultrasmall superparamagnetic particles of iron oxide in acute and chronic soft-tissue infection:: Study in rats
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DOI：
10.1148/radiol.2272020490
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发表时间：
2003-04-01
期刊：
影响因子：
19.7
通讯作者：
Allegrini, PR
中科院分区：
文献类型：
--
作者：
Kaim, AH;Jundt, G;Allegrini, PR
目得：研究磁共振（MR）成像的超小超顺磁性氧化铁颗粒（USPIO）增强的使用，以确定急性，早期慢性和晚期慢性脓肿形成的软组织脓肿的实验模型。材料和方法：在15只大鼠的实验性软组织感染中，在第1和2天（急性）、第5和6天（急性）、第6和7天（急性）用MR成像单元成像。（早期慢性）以及接种感染剂后第8天和第9天（晚期慢性）。所有动物在无对比增强的情况下以及USPIO给药后立即和24小时成像。将MR表现与组织病理学表现进行比较，分析了动物组之间的相对信号强度（SI）以及对比增强（巨噬细胞分布）的程度和模式的变化。结果：USPIO治疗后24 h，脓肿壁相对厚度和相对巨噬细胞数分别为0.50（0.33-0.73）和1.03（0.90-1.08），急性感染为0.11慢性感染早期分别为0.10-0.18和0.94（0.93-1.01），慢性感染晚期分别为0.53（0.44-0.58）和0.80（0.77-0.83）。增强模式（P <0.001），相对SI（P <0.001），相对巨噬细胞范围（P <0.05）随时间的变化是显着的。结论：巨噬细胞的分布模式增加了慢性感染的MR表现的特异性，并允许区分活动性炎症和修复性肉芽组织的区域。(C)RSNA，2003年。
PURPOSE: To investigate the use of magnetic resonance (MR) imaging enhanced with ultrasmall superparamagnetic particles of iron oxide (USPIO) to identify acute, early chronic, and late chronic abscess formation in an experimental model of soft-tissue abscess.MATERIALS AND METHODS: Experimental soft-tissue infection in 15 rats was imaged with an MR imaging unit on days 1 and 2 (acute), days 5 and 6 (early chronic), and days 8 and 9 (late chronic) after inoculation of the infectious agent. All animals were imaged without contrast enhancement and immediately and 24 hours after USPIO administration. MR and histopathologic findings were compared.,The changes in relative signal intensity (SI) and in the extent and pattern of contrast enhancement (macrophage distribution) between the animal groups were analyzed. Statistical testing was performed with Kruskal-Wallis analysis of variance and the chi(2) test.RESULTS: At 24 hours after USPIO administration, the relative 51 of the abscess wall and the relative macrophage extent were 0.50 (0.33-0.73) and 1.03 (0.90-1.08), respectively, for acute infection; 0.11 (0.10-0.18) and 0.94 (0.93-1.01) for early chronic infection; and 0.53 (0.44-0.58) and 0.80 (0.77-0.83) for late chronic infection. The changes in enhancement pattern (P < .001), relative SI (P < .001), and relative macrophage extent (P < .05) with time were significant.CONCLUSION: The macrophage distribution pattern increases the specificity of MR findings in chronic infection and allows differentiation between areas with active inflammation and areas of reparative granulation tissue. (C) RSNA, 2003.