Design and Analysis of Novel Focused Hyperthermia Devices
Design and Analysis of Novel Focused Hyperthermia Devices
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DOI：
10.1109/tmag.2012.2198622
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发表时间：
2012-11-01
影响因子：
2.1
通讯作者：
Fu, W. N.
中科院分区：
文献类型：
--
作者：
Ho, S. L.;Niu, Shuangxia;Fu, W. N.
磁流体热疗(MFH)具有良好的深度穿透性，是一种很有前途的肿瘤治疗方法。由于MFH注入的磁流体不可避免地分布在肿瘤内以及附近的正常组织中，因此很难在不损害周围健康组织的情况下准确地加热和消融目标肿瘤。基于磁性纳米粒子只被交变磁场加热而不被静态直流磁场加热这一观察结果，有可能在MFH治疗中利用这些发现为癌症患者提供有效的治疗。为了避免对健康组织进行不必要的加热，提出了一种在肿瘤靶点周围设置直流磁场的新系统。同时，该系统在目标区域创建了一个静磁场可以忽略的无场区域(FFR)。然后，目标区域可以通过交变磁场被完全加热，而附近的组织不被加热。本文提出了一种新型的交直流联合磁场治疗系统，该系统针对治疗区域，产生精确聚焦的磁场，以消除肿瘤细胞。通过有限元分析对提出的方法进行了验证。
Magnetic fluid hyperthermia (MFH) is a promising cancer therapy by virtue of its good depth penetration. As the injected magnetic fluids of MFH are inevitably distributed in the tumor as well as in normal tissues nearby, it is difficult to accurately heat and ablate the targeted tumor without damaging the surrounding healthy tissues. Based on the observation that magnetic nanoparticles are only heated by alternating fields and not by static dc fields, it is possible to exploit such findings in MFH therapy to provide an efficient cure for cancer patients. To avoid unnecessary heating of healthy tissues, a novel system is proposed to set up a dc magnetic field around the tumor target. At the same time, the system creates a field-free region (FFR) with negligible static magnetic field in the target area. The target area can then be fully heated by an alternating field whereas the nearby tissues are not heated. In this paper, a novel ac and dc magnetic field combined MFH system, targeting the treatment area, is presented to produce an accurately focused magnetic field to abate the tumor cells. The proposed method is validated using finite element analysis.