Cytomegalovirus-Induced Gastrointestinal Bleeding and Pancreatitis Complicating Severe Covid-19 Pneumonia: A Paradigmatic Case
Cytomegalovirus-Induced Gastrointestinal Bleeding and Pancreatitis Complicating Severe Covid-19 Pneumonia: A Paradigmatic Case
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DOI：
10.4084/mjhid.2020.060
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发表时间：
2020-09-01
影响因子：
3.2
通讯作者：
Girelli, Domenico
中科院分区：
文献类型：
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作者：
Marchi, Giacomo;Vianello, Alice;Girelli, Domenico
COVID-19是一种新的大流行性疾病，其病理生理和临床描述尚未完全确定。除呼吸道症状和发热外，胃肠道（GI）症状（尤其包括厌食、腹泻和腹痛）是最常见的临床表现。新的数据指出，严重的SARS-CoV-2感染会导致免疫失调，这反过来可能有利于其他感染。本文报告1例重症COVID-19肺炎患者，在缓解期出现腹痛伴巨细胞病毒（CMV）诱导的肠炎伴出血和胰腺炎，临床表现多样的COVID-19患者应高度怀疑包括CMV在内的多种感染。
COVID-19 is a new pandemic disease whose pathophysiology and clinical description are still not completely defined.Besides respiratory symptoms and fever, gastrointestinal (GI) symptoms (including especially anorexia, diarrhea, and abdominal pain) represent the most frequent clinical manifestations. Emerging data point out that severe SARS-CoV-2 infection causes an immune dysregulation, which in turn may favor other infections. Here we describe a patient with severe COVID-19 pneumonia who developed in the resolving phase abdominal pain associated with cytomegalovirus (CMV)-induced duodenitis with bleeding and pancreatitis.A high level of suspicion toward multiple infections, including CMV, should be maintained in COVID-19 patients with heterogeneous clinical manifestations.