Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease
Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease
复制标题
单核细胞/巨噬细胞中的表观遗传机制对心脏代谢及血管疾病中的炎症反应起调控作用
DOI：
10.1161/atvbaha.118.312135
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发表时间：
2019-04-01
影响因子：
8.7
通讯作者：
Gallagher, Katherine A.
中科院分区：
文献类型：
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作者：
Davis, Frank M.;Gallagher, Katherine A.
心脏代谢和血管疾病及其相关的继发性并发症是西方社会发病率和死亡率的主要原因。慢性炎症是心血管疾病发生和发展的共同基础。在这方面，单核细胞/巨噬细胞是慢性炎症状态发展的关键参与者。在过去的十年中，表观遗传修饰，如DNA甲基化和翻译后组蛋白加工，已成为免疫细胞表型的重要调节因子。越来越多的研究揭示了表观遗传酶在动态调节关键信号通路中的重要性，这些信号通路改变单核细胞/巨噬细胞表型以响应环境刺激。在这篇综述中，我们强调了目前的单核细胞/巨噬细胞极化的范例和新兴的作用，表观遗传修饰的单核细胞/巨噬细胞表型的调节肥胖症，糖尿病，动脉粥样硬化，腹主动脉瘤。
Cardiometabolic and vascular disease, with their associated secondary complications, are the leading cause of morbidity and mortality in Western society. Chronic inflammation is a common theme that underlies initiation and progression of cardiovascular disease. In this regard, monocytes/macrophages are key players in the development of a chronic inflammatory state. Over the past decade, epigenetic modifications, such as DNA methylation and posttranslational histone processing, have emerged as important regulators of immune cell phenotypes. Accumulating studies reveal the importance of epigenetic enzymes in the dynamic regulation of key signaling pathways that alter monocyte/macrophage phenotypes in response to environmental stimuli. In this review, we highlight the current paradigms of monocyte/macrophage polarization and the emerging role of epigenetic modification in the regulation of monocyte/macrophage phenotype in obesity, diabetes mellitus, atherosclerosis, and abdominal aortic aneurysms.