Simultaneous EEG/Functional Magnetic Resonance Imaging at 4 Tesla: Correlates of Brain Activity to Spontaneous Alpha Rhythm During Relaxation
Simultaneous EEG/Functional Magnetic Resonance Imaging at 4 Tesla: Correlates of Brain Activity to Spontaneous Alpha Rhythm During Relaxation
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DOI：
10.1097/wnp.0b013e3181879d56
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Szaflarski, Jerzy P.
中科院分区：
文献类型：
--
作者：
DiFrancesco, Mark W.;Holland, Scott K.;Szaflarski, Jerzy P.
同步EEG和功能性磁共振成像已被应用于使用1.5特斯拉的磁场强度研究与α波相关的大脑状态，近年来已被证明对于其他应用高达3特斯拉是可行的。这项研究证明了这种技术在4特斯拉的场强下的持续可行性，对血氧水平依赖（BOLD）信号的变化具有成比例的更高灵敏度。此外，对于阿尔法相关性的研究。作者使用了比以前工作更多的受试者和扫描会话。随机效应组回归分析35 EEG/功能磁共振成像会议对枕α幅度在放松状态下检测到双侧广泛激活背侧丘脑和部分前扣带和小脑。在同一组的分析中，失活主要出现在梭状和相邻的视觉关联区，在背外侧前额叶皮层也检测到一个小的激活集群。这种模式是一致的α幅度变化和静息状态网络动态之间的对应关系，最近的研究低频自发BOLD波动。丘脑在静息状态网络中的中心作用与α活性相关的突出。证明，高达4特斯拉的同步EEG/功能性磁共振成像的适用性对于涉及挑战性自发性EEG异常（例如癫痫）的临床相关研究特别重要。
Simultaneous EEG and functional magnetic resonance imaging have been applied to the study of brain states associated with alpha waves using a magnetic field strength of 1.5 Tesla and has been shown in recent years to be feasible up to 3 Tesla for other applications. This study demonstrates this technique's continued viability at a field strength of 4 Tesla, affording a proportionally greater sensitivity to changes in Blood Oxygen Level Dependent (BOLD) signal. In addition, for the study of alpha correlations. the authors used a larger number of subjects and scanning sessions than in the previous work. Random effects group regression analysis of 35 EEG/functional magnetic resonance imaging sessions against occipital alpha magnitude in a relaxed state detected bilateral widespread activation of dorsal thalamus and portions of the anterior cingulate and cerebellum. In the same group analysis, deactivations arose predominantly in the fusiform and adjacent visual association areas with a small activation cluster also detected in dorsolateral prefrontal cortex. This pattern is consistent with a correspondence between alpha magnitude variations and resting state network dynamics ascertained by recent studies of low frequency spontaneous BOLD fluctuations. The central role of the thalamus in resting state networks correlated with alpha activity is highlighted. Demonstrating, the applicability Of simultaneous EEG/functional magnetic resonance imaging up to 4 Tesla is particularly important for clinically relevant research involving challenging spontaneous EEG abnormalities, such as those of epilepsy.