Primary cutaneous CD30+anaplastic large-cell lymphomas mimicking keratoacanthomas
Primary cutaneous CD30+anaplastic large-cell lymphomas mimicking keratoacanthomas
复制标题
DOI：
10.1111/j.1365-2230.2007.02477.x
复制
发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Jorda, E.
中科院分区：
文献类型：
--
作者：
Martin, J. M.;Ricart, J. M.;Jorda, E.
原发性皮肤间变性大细胞淋巴瘤（ALCL）可能与角化棘皮瘤（KA）样上皮增生和致密嗜酸性和嗜酸性浸润有关。在这种情况下的诊断是具有挑战性的临床和组织学，因为大的非典型淋巴样细胞可能被掩盖的嗜酸性粒细胞和中性粒细胞的大量浸润，或与浸润性鳞状细胞癌或KA混淆。我们最近遇到了两例CD30+ ALCL，分别在眼睑和鼻子上出现KA样肿瘤。一个显示KA的组织学特征，具有显著的组织嗜酸性粒细胞增多和嗜酸性粒细胞增多。
Primary cutaneous anaplastic large cell lymphoma (ALCL) may be associated with keratoacanthoma (KA)-like epithelial hyperplasia and dense eosinophilic and neutrophilic infiltrates. Diagnosis in such cases is challenging both clinically and histologically, because the large atypical lymphoid cells may be obscured by the massive infiltrate of eosinophils and neutrophils, or confused with invasive squamous cell carcinoma or KA. We recently encountered two cases of CD30+ ALCL presenting with a KA-like tumour on the eyelid and nose, respectively. One showed features of KA histologically, with marked tissue eosinophilia and neutrophilia.