Purinergic signaling during inflammation.
Purinergic signaling during inflammation.
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DOI：
10.1056/nejmra1205750
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发表时间：
2012-12-13
期刊：
影响因子：
--
通讯作者：
Robson SC
中科院分区：
文献类型：
--
作者：
Eltzschig HK;Sitkovsky MV;Robson SC
ATP 和 ADP 以及腺苷的受体发挥多种作用。 ATP和ADP信号传导主要是促炎性的，腺苷信号传导主要是抗炎性的。这些核苷的受体正在成为许多炎症和自身免疫性疾病的治疗靶点。
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.