Missed treatment opportunities for schistosomiasis mansoni, in an active programme for the treatment of urinary schistosomiasis in Plateau and Nasarawa states, Nigeria
Missed treatment opportunities for schistosomiasis mansoni, in an active programme for the treatment of urinary schistosomiasis in Plateau and Nasarawa states, Nigeria
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DOI：
10.1179/136485908x278810
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发表时间：
2008-06-01
影响因子：
--
通讯作者：
Richards, F. O., Jr.
中科院分区：
文献类型：
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作者：
Gutman, J.;Fagbemi, A.;Richards, F. O., Jr.
埃及血吸虫和S.曼索尼病是尼日利亚的地方病。自1999年以来，高原州和纳萨拉瓦州卫生部在卡特中心的协助下，向村庄提供了吡喹酮的大规模药物管理，在这些村庄，超过20%的学龄儿童经尿液试纸检测发现有血尿（推测是由S.嗜血杆菌属）。S.在尼日利亚，曼氏疟原虫仍然相对不为人知，因为在许多流行地区很难进行检测人类感染这种寄生虫所需的测试。在一项涉及924名儿童的横断面调查中，S。在30个村庄（在4个地方政府辖区内）确定了mansoni，这些村庄被排除在大规模吡喹酮管理之外，因为发现其学龄儿童的血尿患病率<20%。有17个（57%）被调查的村庄有足够的S。曼森氏病（即患病率至少为10%），以保证治疗。结果表明，如果S. haematobium和S.在所研究的四个地方政府区域中，81%的那些村庄需要治疗，而如果只考虑S.血吸虫被认为是。目前，逐村诊断S。haematobium和S. mansoni将大于所有村庄学龄儿童的假定待遇。除非改进和廉价的快速诊断方法，S。因此，在尼日利亚的这一地区，解决血吸虫病总体问题的最廉价方法是大规模分发药物，而不对高危人群进行筛查。
Both Schistosoma haematobium and S. mansoni are endemic in Nigeria. Since 1999 the ministries of health of Plateau and Nasarawa states, assisted by The Carter Center, have provided mass drug administrations with praziquantel to villages where > 20% of the school-aged children tested with urine dipsticks have been found to have haematuria (presumed to be caused by S. haematobium). The current extent of S. mansoni in Nigeria remains relatively unknown because the tests needed to detect human infection with this parasite are difficult to perform in many endemic areas. In a cross-sectional survey involving 924 children, the prevalence of S. mansoni was determined in 30 villages (in four local government areas) that had been excluded from mass praziquantel administrations because the prevalence of haematuria in their school-aged children had been found to be < 20%. Seventeen (57%) of the surveyed villages had sufficient S. mansoni (i.e. prevalences of at least 10%) to warrant treatment. The results indicated that, if both S. haematobium and S. mansoni are taken into account, 81% of the villages in the four local government areas studied require treatment, compared with 50% if only S. haematobium is considered. At the moment, the costs of the village-by-village diagnosis of S. haematobium and S. mansoni would be greater than those of the presumptive treatment of the school-aged children in all villages. Until improved and cheaper rapid diagnostic methods for S. mansoni become available, the cheapest approach to the overall problem of schistosomiasis in this part of Nigeria would therefore be wide-spread mass drug distributions, without screening for at-risk populations.