Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer
Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer
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DOI：
10.1080/23723556.2015.1029065
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Kale, Abhijit
中科院分区：
文献类型：
--
作者：
Baker, Nicholas E.;Kale, Abhijit
影响多种核糖体蛋白的突变与癌症有关。利用果蝇中的遗传嵌合体，我们描述了影响 Rp/Rp 纯合突变细胞、Rp/C 杂合细胞或与附近野生型细胞竞争的 Rp/C 杂合细胞的 3 种凋亡机制，并讨论了细胞凋亡如何与癌症易感性相关。
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/C heterozygous cells, or Rp/C heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.