High-resolution whole-brain diffusion MRI at 3T using simultaneous multi-slab (SMSlab) acquisition
High-resolution whole-brain diffusion MRI at 3T using simultaneous multi-slab (SMSlab) acquisition
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DOI：
10.1016/j.neuroimage.2021.118099
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发表时间：
2021-05-12
期刊：
影响因子：
5.7
通讯作者：
Guo, Hua
中科院分区：
文献类型：
--
作者：
Dai, Erpeng;Liu, Simin;Guo, Hua
高分辨率弥散磁共振成像（dMRI）是神经科学研究中检测精细纤维结构、描绘复杂纤维结构和分析皮质各向异性的重要工具。然而，由于扩散衰减，高分辨率dMRI受到其固有的低SNR的限制。人们已经提出了一系列的技术来提高信噪比的性能，但大多数都是以长扫描时间为代价的，这反过来又牺牲了信噪比的效率，特别是对于大视场成像，如全脑成像。最近，3D多板采集和同时多切片（SMS）激发的组合，即同时多板（SMSlab），已经被证明具有用于具有高SNR和SNR效率的高分辨率扩散成像的潜力。在我们以前的工作中，我们提出了一个三维傅立叶编码和重建框架SMSlab采集。在这项研究中，我们通过开发一种新的导航采集策略和探索基于k空间的相位校正方法，将这种3D k空间框架扩展到扩散成像。使用所提出的SMSlab方法采集体内脑数据，并与一系列不同的采集进行比较，包括传统的3D多厚片、2D SMS和2D单次激发EPI（ss-EPI）采集。结果表明，SMSlab具有更好的SNR性能相比，三维多板和二维SMS。与使用常规2D ss-EPI的低分辨率扩散成像相比，使用SMSlab提高了精细纤维结构的检测能力。
High-resolution diffusion MRI (dMRI) is a crucial tool in neuroscience studies to detect fine fiber structure, depict complex fiber architecture and analyze cortical anisotropy. However, high-resolution dMRI is limited by its intrinsically low SNR due to diffusion attenuation. A series of techniques have been proposed to improve the SNR performance, but most of them are at the cost of long scan time, which in turn sacrifice the SNR efficiency, especially for large FOV imaging, such as whole-brain imaging. Recently, a combination of 3D multi-slab acquisition and simultaneous multi-slice (SMS) excitation, namely simultaneous multi-slab (SMSlab), has been demonstrated to have potential for high-resolution diffusion imaging with high SNR and SNR efficiency. In our previous work, we have proposed a 3D Fourier encoding and reconstruction framework for SMSlab acquisition. In this study, we extend this 3D k-space framework to diffusion imaging, by developing a novel navigator acquisition strategy and exploring a k-space-based phase correction method. In vivo brain data are acquired using the proposed SMSlab method and compared with a series of different acquisitions, including the traditional 3D multi-slab, 2D SMS and 2D single-shot EPI (ss-EPI) acquisitions. The results demonstrate that SMSlab has a better SNR performance compared with 3D multi-slab and 2D SMS. The detection capacity of fine fiber structures is improved using SMSlab, compared with the low-resolution diffusion imaging using conventional 2D ss-EPI.