Interplay of extracellular matrix and leukocytes in lung inflammation.
Interplay of extracellular matrix and leukocytes in lung inflammation.
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DOI：
10.1016/j.cellimm.2016.12.003
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发表时间：
2017-02
影响因子：
4.3
通讯作者：
Ziegler SF
中科院分区：
文献类型：
--
作者：
Wight TN;Frevert CW;Debley JS;Reeves SR;Parks WC;Ziegler SF
在炎症过程中，白细胞流入肺室并与细胞外基质（ECM）相互作用。两种ECM成分，多功能蛋白聚糖和透明质酸，在一系列肺部疾病中增加。白细胞与这些ECM组分的相互作用控制白细胞保留和积累、增殖、迁移、分化和活化，作为肺部疾病炎症阶段的一部分。此外，来自哮喘儿童的支气管上皮细胞与人肺成纤维细胞共培养产生粘附单核细胞/巨噬细胞的ECM。巨噬细胞存在于早期和晚期肺部炎症中。基质金属蛋白酶10（MMP 10）在损伤和感染的肺泡巨噬细胞中被诱导，并调节巨噬细胞表型及其降解胶原ECM组分的能力。总的来说，本综述中概述的研究强调了特定ECM组分在调节肺部疾病炎症事件中的重要性。这些ECM组分在肺部炎症的发病机制中的广泛参与使它们成为治疗干预的有吸引力的候选者。
During inflammation, leukocytes influx into lung compartments and interact with extracellular matrix (ECM). Two ECM components, versican and hyaluronan, increase in a range of lung diseases. The interaction of leukocytes with these ECM components controls leukocyte retention and accumulation, proliferation, migration, differentiation, and activation as part of the inflammatory phase of lung disease. In addition, bronchial epithelial cells from asthmatic children co-cultured with human lung fibroblasts generate an ECM that is adherent for monocytes/macrophages. Macrophages are present in both early and late lung inflammation. Matrix metalloproteinase 10 (MMP10) is induced in alveolar macrophages with injury and infection and modulates macrophage phenotype and their ability to degrade collagenous ECM components. Collectively, studies outlined in this review highlight the importance of specific ECM components in the regulation inflammatory events in lung disease. The widespread involvement of these ECM components in the pathogenesis of lung inflammation make them attractive candidates for therapeutic intervention.