Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control
Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control
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DOI：
10.1016/j.ijrobp.2005.10.003
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发表时间：
2006-03-15
影响因子：
7
通讯作者：
Nakano, T
中科院分区：
文献类型：
--
作者：
Akimoto, T;Nonaka, T;Nakano, T
目的：评价同期化疗对T2N0喉癌放疗患者局部控制的影响。方法与材料：分析63例T2N0喉癌患者接受确定性放疗的临床资料。原发灶位于声门50例，声门上9例，声门下4例。结果：单纯放疗组和同期放疗组的完全缓解率分别为92%和100%。CRT组的嗓音保留率(89%)明显高于单纯RT组(61%)。同时接受CRT治疗的患者的5年无瘤生存率明显优于单纯接受RT治疗的患者，但两组患者的病因特异性生存率没有显著差异。多因素分析显示，放疗方式(单纯放疗与放疗)是预测放疗后复发的最显著危险因素。结论：同期放疗对T2N0喉癌的局部控制有积极作用。(C)2006年爱思唯尔公司。
Purpose: The impact of concurrent chemotherapy on the local control in patients with T2N0 laryngeal cancer who receive radiation therapy (RT) was evaluated.Methods and Materials: Sixty-three patients with T2N0 laryngeal cancer who were treated by definitive RT were analyzed. The primary site of the cancer was the glottis in 50 patients, the supraglottis in 9 patients, and the subglottis in 4 patients. Thirty-six patients were treated by RT alone and the remaining 27 patients received concurrent chemoradiotherapy (CRT).Results: Complete response (CR) was obtained in 92% of the patients who received RT alone and 100% of the patients who received CRT. Voice preservation in the group who received CRT (89%) was significantly higher than that in the group treated by RT alone (61%). The 5-year disease-free survival rates in those who received concurrent CRT was significantly superior to that in the patients who received RT alone, although no significant difference was seen in the cause-specific survival rate between the 2 groups. The multivariate analysis revealed that the treatment method (RT alone vs. CRT) was the most significant risk factor that predicted recurrence after RT.Conclusion: Concurrent CRT had a positive impact on the local control of T2N0 laryngeal cancer. (C) 2006 Elsevier Inc.