Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems
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DOI：
10.1007/978-1-4939-3112-5_4
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Cheng, Jianjun
中科院分区：
文献类型：
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作者：
Yin, Lichen;Zheng, Nan;Cheng, Jianjun
近年来，小干扰RNA （SiRNA）介导的RNA干扰（RNAi）被认为是一种有效的基因翻译后调控机制。尽管它具有效率和特异性，但阻碍其广泛应用的最大障碍是将SiRNA货物安全有效地递送到靶细胞中。在这里，我们描述了阳离子螺旋多肽和多肽基纳米系统在体外和体内通过口服给药介导的高效SiRNA递送。
RNA interference (RNAi) mediated by small interfering RNA (SiRNA) has recently emerged as a potent machinery in regulating gene expression at the post-translation step. Despite its efficiency and specificity, the biggest hurdle against its wide application is the safe and effective delivery of the SiRNA cargo into target cells. Here, we describe the highly effective SiRNA delivery mediated by the cationic helical polypeptides and polypeptide-based nanosystems both in vitro and in vivo via oral administration.